Synthesis, crystal structure, and chromotropism properties of Dihalo N-2-ethanolpicolylamine copper(II)

Nadarkhani, Saba; Golchoubian, Hamid; Shirvan, Atie

doi:10.1016/j.molstruc.2022.134801

Cited by 3 publications

(2 citation statements)

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“…Compound 1 shows a geometry (square pyramidal) similar to that reported for the [Cu(HL)(NO 3 ) 2 ] complex that also contains the HL ligand and nitrate anions . A copper complex containing a ligand ( N -2-ethanolpicolylamine) similar to HL was also reported recently and shows a square pyramidal structure similar to that observed in 1 …”

Section: Resultssupporting

confidence: 69%

“…92 A copper complex containing a ligand (N-2-ethanolpicolylamine) similar to HL was also reported recently and shows a square pyramidal structure similar to that observed in 1. 111 In 1, both HL and a chlorido ligand occupy the basal plane while the second chlorido ligand is present in the apical position (Figure 2). The HL ligand binds in a meridional fashion to the Cu(II) ion via the pyridine (N12), amine (N1), and alcohol (O1) groups as observed for a Zn(II) complex synthesized with the same ligand.…”

Section: •−mentioning

confidence: 99%

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A Multipurpose Metallophore and Its Copper Complexes with Diverse Catalytic Antioxidant Properties to Deal with Metal and Oxidative Stress Disorders: A Combined Experimental, Theoretical, and In Vitro Study

Menezes,

Sampaio,

Meurer

et al. 2024

Inorg. Chem.

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We report the discovery that the molecule 1-(pyridin-2-ylmethylamino)propan-2-ol (HL) can reduce oxidative stress in neuronal C6 glioma cells exposed to reactive oxygen species (O 2 −• , H 2 O 2 , and • OH) and metal (Cu + ) stress conditions. Furthermore, its association with Cu 2+ generates [Cu(HL)Cl 2 ] (1) and [Cu(HL) 2 ](ClO 4 ) 2 (2) complexes that also exhibit antioxidant properties. Potentiometric titration data show that HL can coordinate to Cu 2+ in 1:1 and 1:2 Cu 2+ :ligand ratios, which was confirmed by monocrystal X-ray studies. The subsequent ultraviolet−visible, electrospray ionization mass spectrometry, and electron paramagnetic resonance experiments show that they can decompose a variety of reactive oxygen species (ROS). Kinetic studies revealed that 1 and 2 mimic the superoxide dismutase and catalase activities. Complex 1 promotes the fastest decomposition of H 2 O 2 (k obs = 2.32 × 10 7 M −1 s −1 ), efficiently dismutases the superoxide anion (k cat = 3.08 × 10 7 M −1 s −1 ), and scavenges the hydroxyl radical (RSA 50 = 25.7 × 10 −6 M). Density functional theory calculations support the formation of dinuclear Cu-peroxide and mononuclear Cu-superoxide species in the reactions of [Cu(HL)Cl 2 ] with H 2 O 2 and O 2•− , respectively. Furthermore, both 1 and 2 also reduce the oxidative stress of neuronal glioma C6 cells exposed to different ROS, including O 2•− and • OH.

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Section: Resultssupporting

confidence: 69%

Section: •−mentioning

confidence: 99%