Synthesis, Crystal Structure, and DNA-Binding Studies of a Nickel(II) Complex with the Bis(2-benzimidazolymethyl)amine Ligand

Abstract

A V-shaped ligand Bis(2-benzimidazolymethyl)amine (bba) and its nickel(II) picrate (pic) complex, with composition [Ni(bba)2](pic)2·3MeOH, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/vis measurements. In the complex, the Ni(II) ion is six-coordinated with a N2O4 ligand set, resulting in a distorted octahedron coordination geometry. In addition, the DNA-binding properties of the Ni(II) complex have been investigated by electronic absorption, fluorescence, and viscosity measurements. The experimental results suggest that the nickel(II) complex binds to DNA by partial intercalation binding mode.

Synthesis, Structural Characterization Of Benzothiazole Schiff Base Metal (II) Complexes And Their Interaction With DNA

“…This is shown in Fig. 5.5, that the significant hypochromism (H%) was observed in the absorption spectrum of the metal complexes associated with CT-DNA, which is attributed to atomic interactions between molecules and the DNA [28]. The visible absorption spectra of all compounds show distinct and larger MLCT transitions.…”

Biomimicking Oxidative Bromination and DNA Nuclease Activities of a New Structurally Characterised Oxido-Diperoxidomolybdenum(VI) Complex

“…The observed hypochromicity suggests that the complex might bind to the minor groove of DNA by partial intercalation . The binding constant of the DNA‐complex species was calculated to be (8.14 ± 0.03) x10 3 M −1 which suggests that the complex binds to DNA with an affinity much less than that of classical intercalators …”

Anticancer, Antibacterial, Antioxidant, and DNA‐Binding Study of Metal‐Phenalenyl Complexes

“…Due to the high intercalation of EB between DNA base pairs, EB exhibited strong fluorescence in the presence of DNA, and EB fluorescence can be quenched by adding a second EB molecule [ 57 ]. The extent of binding of the second molecule to DNA can be indirectly determined by the quenching of EB fluorescence.…”

“…The fluorescence spectra of EB were measured using an excitation wavelength of 525 nm, and the emission spectra were recorded between 550 and 750 nm. The spectra were analyzed according to the classical Stern–Volmer equation: where I 0 and I are the fluorescence intensities at 595 nm in the absence and presence of the quencher, respectively; K sv is the linear Stern–Volmer quenching constant; and (Q) is the ratio of concentrations of quencher and SS-DNA [ 41 , 57 ].…”