Synthesis, Crystal Structure and Fluorescence Properties of Three 1-D Coordination Polymers Based on Fluconazole

5 ]$5H 2 O} n (4), in the presence of ancillary ligands (4,4 0 -bpy ¼ 4,4 0 -bipyridine, 1,4-bib ¼ 1,4-bis(1-imidazolyl)benzene). Their structures were determined by single-crystal X-ray diffraction analyses and further characterized by IR spectra, elemental analyses, powder X-ray diffraction (PXRD), and thermogravimetric (TG) analyses. Complex 1 exhibits a 3D framework with one-dimensional channels along the [111] direction, which can be defined as a (4,10)-connected deh1 net with the point Schläfli symbol of {3$4 5 } 2 {3 4 $4 12 $5 10 $6 14 $7 3 $8 2 }. Compound 2 contains two interpenetrated 3D networks, each of which can be viewed as a (4,4)-connected mog moganite network with the point Schläfli symbol of {4$6 4 $8} 2 {4 2 $6 2 $8 2 }. In Complex 3, both the Hbptc 3À and the 1,4-bib show m 2 coordination mode, the former of which links two Co2 cations to form a 1D anionic chain and the latter of which links two Co1 cations to generate a 1D cationic chain. Interestingly, the 1D anionic chains are assembled through abundant strong hydrogen bonds to generate a 3D supermolecular structure with large one-dimensional channels occupied by the 1D cationic chains along the c axis. Complex 4 consists of two interpenetrated 3D networks, each of which can be simplified as a novel (3,4,4)-connected framework with the point Schlafi symbol of {4$6$8}{4$6 3 $8 2 }{6 4 $8$10}. In addition, the magnetic properties for 1, 2 and the photoluminescent properties for 3, 4 were investigated. The magnetic results show that there exist antiferromagnetic interactions between Cu(II) ions in 1 and 2.

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Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery

Cortat,

Zobi

2023

Pharmaceutics

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Coordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work performed in the field of coordination derivatives of AAs synthesized for medical purposes by discussing the corresponding publications and emphasizing the most promising compounds discovered so far. The resulting overview highlights the efficiency of AAs and their metallic species, as well as the potential still lying in this research area.

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Synthesis, Crystal Structure and Fluorescence Properties of Three 1-D Coordination Polymers Based on Fluconazole

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References 22 publications

One novel 3D tetranuclear cadmium coordination polymer based on 2,3′,4,5′-biphenyltetracarboxylic acid: Synthesis, crystal structure and luminescence

One novel 3D tetranuclear cadmium coordination polymer based on 2,3′,4,5′-biphenyltetracarboxylic acid: Synthesis, crystal structure and luminescence

Syntheses, crystal structures, photoluminescent/magnetic properties of four new coordination polymers based on 2,3′,4,5′-biphenyltetracarboxylic acid

Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery

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