Synthesis, Crystal Structure, and Spectral Characterization of Flumatinib Mesylate

Xu, Gang; Shen, Hong; Tong, Taifeng; Lu, A.; Gou, Shaohua

doi:10.1080/00397910903289248

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Oncology Drugs2

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2012

2022

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Cited by 9 publications

(2 citation statements)

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“…Although several strategies for the synthesis of flumatinib have been reported, researchers at Hansoh Pharma recently published a patent describing a process route to the drug (Scheme ). Sulfonyl pyrimidine 278 and nitropyridine 279 underwent a substitution reaction to produce the aminopyrimidine core structure 280 in 83% yield .…”

Section: Oncology Drugsmentioning

confidence: 99%

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Synthetic Approaches to the New Drugs Approved during 2019

et al. 2021

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New drugs introduced to the market are privileged structures having affinities for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small molecules and antibody–drug conjugates, provide insight into molecular recognition and simultaneously function as leads for the design of future medicines. This review is part of a continuing series presenting the most likely process-scale synthetic approaches to 40 NCEs approved for the first time anywhere in the world in 2019.

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Section: Oncology Drugsmentioning

confidence: 99%

“…Amide 282 originated from benzonitrile 283 (Scheme ). Bromination of this tolyl derivative followed by substitution with N -methylpiperazine ( 254 ) and subsequent palladium-catalyzed conversion of the nitrile to the primary amide proceeded in excellent yield across the two-step sequence …”

Section: Oncology Drugsmentioning

confidence: 99%