Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline

In vitro cytotoxicity, DNA cleavage and SOD-mimic activity of copper(II) mixed-ligand quinolinonato complexes

“…1.8-1.9, indicating that CT-DNA was sufficiently free of protein [39]. The evidence of DNA interactions was evaluated by changes in the charge-transfer region of spectra of the complex-DNA mixture, which is spectroscopically manifested by bathochromic (red-shift), hypsochromic (blue-shift), or hypochromic effects [40].…”

Synthesis, crystal structure, DNA interaction and antioxidant activities of two novel water-soluble Cu(2+) complexes derivated from 2-oxo-quinoline-3-carbaldehyde Schiff-bases

“…Generally, the transition metals play a very important role in organism and their complexes can interact non-covalently with nucleic acid by intercalation, groove-binding or external electrostatic binding for cations [3,[7][8][9][10][11]. And that many transition metal complexes have been investigated to be utilized as probes of DNA structure, agents for mediation of strand scission of duplex DNA and chemotherapeutic agents [12][13][14]. Most notably, some Pt(2þ) complexes (cisplatin and carboplatin) have found their way into the pharmaceutical armamentarium as applied clinical antitumor drugs [15].…”

Carbazole tricationic salt: A novel potential two-photon fluorescent DNA probe for nucleic imaging of cells

“…With the addition of DNA, the absorbance value decreases when the ratio of phosphate of DNA to compound is lower than 5 and then increases. The absorbance changes and red-shift occurs with the addition of DNA suggests that this compound can strongly bind to DNA [28,29]. The hypochromism in the electronic absorption spectra may be attributed to the strong interaction between the electronic states of the intercalating chromophore and those of the bases in the DNA [30], while the hyperchromism is thought to be due to external contact (surface binding) with the duplex [31].…”