Synthesis, crystal structure, characterisation, and antifungal activity of 3-thiophene aldehyde semicarbazone (3STCH), 2,3-thiophene dicarboxaldehyde bis(semicarbazone) (2,3BSTCH2) and their nickel (II) complexes

UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

“…[50] It is now generally assumed that antimicrobial activity of lichenic extracts depend on the tested microorganism, the lichen species, and its concentration. [57] [58] Lichenic substances have seldom been identified as exhibiting some antifungal activities. To the best of our knowledge, this lichen, formerly named R. fucoides, [55] has only been reported for its capacity to inhibit the in vitro germination of wheat seeds.…”

“…It is worthwhile to note that lipophilicity is a factor to be considered to explain the observed activity, since low polarity seems to be required for compounds or extracts to pass through the fungal cell wall. [57] [58] Lichenic substances have seldom been identified as exhibiting some antifungal activities. Ethyl orsellinate and methyl b-orsellinate [7] were listed to be active against C. albicans.…”

“…Tests were performed according to a procedure described by Alomar et al, [57] following the guidelines of the approved reference method of the National Committee for Clinical Laboratory Standards (NCCLS) for yeasts [64] and filamentous fungi. [65] Briefly, the yeast suspensions were prepared in RPMI-1640 culture medium and adjusted spectrophotometrically at 630 nm to reach a final concentration around 0.5 9 10 3 to 2.5 9 10 3 cells/mL.…”

Practical one-pot synthesis of semicarbazone derivatives via semicarbazide, and evaluation of their antibacterial activity

“…Semicarbazone derivatives have versatile biological activities, making their study interesting: anticonvulsant [1-3], antimicrobial [4,5], antioxidant [6], antiangiogenic [7], anticancer [8], antiproliferative [9], antimalarial [10], and antiprotozoal [11]. In addition, steroidal semicarbazone derivatives have shown antiproliferative activity [12], indole semicarbazones exhibited antimicrobial activity [13], and semicarbazone derivatives of calix [4]arene have been used for removal of Cr(VI) ions [14].…”

“…Moreover, semicarbazones behave as chelating ligands due to their N and O atoms and electron delocalization along the semicarbazone moiety. Various semicarbazone complexes have been synthesized that exhibit biological activities, for example, nickel(II) complexes of 3-thiophene aldehyde semicarbazone, 2,3-thiophene dicarboxaldehyde bis(semicarbazone) have shown antifungal activity [17]; antioxidant and anticancer activity of ruthenium(II) complexes of semicarbazone bearing 9,10-phenanthrenequinone moiety have been studied [18]; anticancer activity of copper(II), vanadium(IV/V), iron(II)/(III), and gallium(III) complexes of salicylaldehyde semicarbazone and its bromo derivative have been reported [19]; Cu(II), Zn(II), Ni(II) complexes of 3-carbaldehyde-chromone semicarbazone have DNA binding properties and antioxidant activities [20]; organotin(IV) complexes of semicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde have shown antimicrobial activity [21]. In addition, palladium complexes of semicarbazones have been used as catalysts in Suzuki and Sonogashira cross-coupling reactions [22].…”