Synthesis, crystal structure description, electrochemical, and DNA-binding studies of “paddlewheel” copper(II) carboxylate

Iqbal, Muhammad; Ali, Saqib; Rehman, Zia ur; Muhammad, Niaz; Sohail, Manzar; Pandarinathan, Vedapriya

doi:10.1080/00958972.2014.926337

Cited by 32 publications

(12 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All the data of bond lengths and angles are comparable with previously reported similar Cu(II) complexes with O-and N-donor ligands. 35,36 Supramolecular interactions in complexes are different from one another owing to different dihedral planes and the presence of CHCl 3 in 2. In complex 1 two molecules of 3-chlorophenylacetate form different dihedral angles around copper which enable them to take part in C-H···O interactions with 1,10-phenanthroline moiety of the neighboring molecule.…”

Section: Crystal Structure Descriptionmentioning

confidence: 99%

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Mushtaq

Ali

Tahir

et al. 2017

ACSi

Self Cite

View full text Add to dashboard Cite

Two new binuclear O-bridged copper(II) carboxylates with chemical formulas [Cu 2 (3-ClC 6 H 4 CH 2 COO) 4 (phen) 2 ] (1) and [Cu 2 (3-ClC 6 H 4 CH 2 COO) 4 (bipy) 2 ] (2) where phen = 1,10-phenanthroline and bipy = 2,2'-bipyridine have been synthesized and characterized by FT-IR, UV-Visible spectroscopy, CHN analysis and single crystal XRD. The results revealed distorted square pyramidal geometry around each copper atom of 1 and 2. The DNA interaction studies showed strong binding with K b = 5.07 × 10 3 and 4.62 × 10 3 M -1 for 1 and 2, respectively. Both complexes showed strong enzyme inhibition, i.e., 70% and 90% for α-glucosidase with IC 50 = 34.6 and 30.1 μM for 1 and 2, respectively, where acarbose was employed as control. However, both the complexes were found inactive against α-amylase. Using galantamine hydrobromide as control, 1 showed moderate inhibition activity (47%) with IC 50 = 179.4 μM for acetylcholine esterase whereas 2 showed strong inhibition activity (76%) with IC 50 = 95.8 μM for butyrylcholine esterase. The data reflects active anti-diabetic and anti-Alzheimer's nature of the synthesized complexes.

show abstract

Section: Crystal Structure Descriptionmentioning

confidence: 99%

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Mushtaq

Ali

Tahir

et al. 2017

ACSi

Self Cite

View full text Add to dashboard Cite

show abstract

“…The intense absorption bands at short wavelengths, 300-500 nm, may be assigned to (n-π*) and (π-π*) transitions [45]. The absorptions at 750 nm may be assigned to d-d transitions [41]. Complexes 1-3 exhibit luminescence in methanol.…”

Section: Geometry Optimizationmentioning

confidence: 97%

Variation in crystalline architectures through supramolecular interactions in copper(II) complexes with tridentate N₂O donor Schiff bases

Jana

Chattopadhyay

2015

Journal of Coordination Chemistry

View full text Add to dashboard Cite

2 )]ClO 4 (3), where HL 1 = 4-bromo-2-(-(quinolin-8-ylimino)methyl) phenol and HL 2 = 1-(-(quinolin-8-ylimino)methyl)naphthalen-2-ol, have been prepared and characterized by elemental analysis, IR, UV-vis and fluorescence spectroscopy and single-crystal X-ray diffraction studies. The copper(II) centers assume five-coordinate square-pyramidal geometries in 1 and 2, whereas square planar copper(II) is present in 3. A methanol molecule has been inserted in the pendant end of the ligated dicyanamide in 3. Various supramolecular architectures are formed by hydrogen bonding, π⋯π, C-H⋯π, and lp⋯π interactions.

show abstract

“…From the [DNA]/(ε a − ε f ) versus [DNA] plot (inset in figure 4), the K b value for 1 was estimated to be 6.16 × 10 4 M −1 (R = 0.9989 for six points), lower than that of a classical intercalator, such as EB-DNA [41], but higher than those of some bi- [42][43][44] and tetracopper(II) complexes [45], and has the same level as those of well-established intercalation agents [46], indicating that 1 strongly binds to HS-DNA, and this may be related to structural characteristics. Comparing the K b value of 1 (K b , 6.16 × 10 4 M −1 ) with those of our previously reported analogous polymeric copper(II) complexes {[Cu 2 (dmaepox)(dabt)](pic)·H 2 O} n (K b , 1.25 × 10 4 M −1 ) and {[Cu 2 (dmapob)(dabt)](NO 3 )·0.6H 2 O} n (K b , 1.04 × 10 4 M −1 ) [20], the K b value of 1 is higher than those of the previously reported polymeric copper(II) complexes, indicating that 1 strongly binds to HS-DNA by intercalation.…”

Section: Dna Interaction Studiesmentioning

confidence: 99%

Synthesis and structure of a 1-D copper(II) coordination polymer bridged both by oxamido and carboxylate: in vitro anticancer activity and reactivity toward DNA and protein BSA

Zheng

et al. 2015

Journal of Coordination Chemistry

View full text Add to dashboard Cite

2015) Synthesis and structure of a 1-D copper(II) coordination polymer bridged both by oxamido and carboxylate: in vitro anticancer activity and reactivity toward DNA and protein BSA, Journal of Coordination Chemistry, 68:5, 928-948, A new 1-D copper(II) coordination polymer was synthesized and structurally characterized. In vitro anticancer activity and reactivity toward DNA and protein of the copper(II) polymer was studied.A 1-D copper(II) coordination polymer formulated as {[Cu 2 (bdpox)(dabt)](NO 3 )·H 2 O} n , where H 3 bdpox and dabt denote N-benzoate-N′-[3-(diethylamino)propyl]oxamide and 2,2′-diamino-4,4′-bithiazole, respectively, was synthesized and characterized by elemental analyses, molar conductance *Corresponding authors.Downloaded by [University of Saskatchewan Library] at 07:16 17 March 2015 measurement, IR and electronic spectra studies, and single-crystal X-ray diffraction. The crystal structure analysis reveals that copper(II) ions are bridged by both cis-oxamido and carboxylato groups to form a 1-D coordination polymer with corresponding Cu···Cu separations of 5.2420(10) and 5.1551(8) Å. The endo-and exo-copper(II) ions of the cis-oxamido-bridge are located in distorted square-planar and square-pyramidal geometries, respectively. There is a 2-D hydrogen bonding network in the crystal. The in vitro anticancer activities suggest that the copper(II) complex is active against selected tumor cell lines. The reactivities toward herring sperm DNA and bovine serum albumin (BSA) reveal that the copper(II) complex can interact with DNA by intercalation and effectively quench the intrinsic fluorescence of BSA via a static mechanism. The influence of hydrophobicity of the substituents in bridging ligands on DNA and protein binding properties and the in vitro anticancer activities of such copper(II) polymers is discussed.

show abstract

Synthesis, crystal structure description, electrochemical, and DNA-binding studies of “paddlewheel” copper(II) carboxylate

Cited by 32 publications

References 62 publications

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Variation in crystalline architectures through supramolecular interactions in copper(II) complexes with tridentate N₂O donor Schiff bases

Synthesis and structure of a 1-D copper(II) coordination polymer bridged both by oxamido and carboxylate: in vitro anticancer activity and reactivity toward DNA and protein BSA

Contact Info

Product

Resources

About

Synthesis, crystal structure description, electrochemical, and DNA-binding studies of “paddlewheel” copper(II) carboxylate

Cited by 32 publications

References 62 publications

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Variation in crystalline architectures through supramolecular interactions in copper(II) complexes with tridentate N2O donor Schiff bases

Synthesis and structure of a 1-D copper(II) coordination polymer bridged both by oxamido and carboxylate: in vitro anticancer activity and reactivity toward DNA and protein BSA

Contact Info

Product

Resources

About

Variation in crystalline architectures through supramolecular interactions in copper(II) complexes with tridentate N₂O donor Schiff bases