Synthesis, Crystal Structure, DNA‐binding Properties and Antioxidant Activity of a Copper(II) Complex with Naphthalimide Schiff Base

Abstract

The Schiff N‐allylamine‐4‐(ethylenediamine‐5‐methylsalicylidene)‐1,8‐naphthalimide (H2L) and its copper(II) complex, [Cu(HL)2]·0.5DMF, were synthesized and characterized. The crystal structure of the CuII complex reveals a slightly distorted square‐planar arrangement provided by two N and O donors from two deprotonated ligands. In addition, the DNA‐binding properties of the ligand and CuII complex were investigated by fluorescence spectra, electronic absorption, and viscosity measurements. The experimental studies of the DNA‐binding properties indicated that the ligand and CuII complex reacted with DNA via intercalation binding mode, and binding affinity for DNA takes the order: ligand > CuII complex. The antioxidant assay in vitro suggested that both exhibited potential intensely antioxidant properties, and the ligand is more effective than its CuII complex.

Synthesis, crystal structure, fluorescence and antioxidant properties of a binuclear Ag(I) complex based on the SPPh3 ligand

“…Moreover, using the same method, we compared the abilities of the compound to scavenge hydroxyl radical (OH•) with those of the well-known natural antioxidants mannitol (IC 50 = 9.6 × 10 -3 M) and vitamin C(IC 50 = 8.7 × 10 -3 M). 42,43 The results suggests that complex 1 has a higher ability to scavenge hydroxyl radical(OH•) than mannitol and vitamin C. = 6.02 × 10 -5 M) in the literature. 44,45 As a result, complex 1 can be considered as a new potential antioxidant.…”

Copper(i) complexes with quinolone appended 1,8-naphthalimide conjugates: structural characterization, DNA and protein binding and cytotoxicity studies

“…Electronic absorption spectroscopy has been widely used for analyzing metal complex interactions with DNA. 65 The absorption spectra of complex 1 in the absence and presence of CT-DNA have been shown in Fig. 4.…”

Unprecedented Dinuclear CuII N,O-Donor Complex: Synthesis, Structural Characterization, Fluorescence Property, and Hirshfeld Analysis

“…About two weeks later, some bright brown block-like crystals suitable for X-ray diffraction were gained and collected carefully. Yield: 54 The synthetic route to the Cu II complex is depicted in Scheme 2. An acetone solution (3 mL) of HL 1 (10.60 mg, 0.04 mmol) was added to a methanol solution (3 mL) of Cu(OAc)2·H2O (7.96 mg, 0.04 mmol).…”