Synthesis, crystal structure, nuclease and in vitro antitumor activities of a new mononuclear copper(II) complex containing a tripodal N3O ligand

A new μ-oxo di-iron complex with suitable features to mimic metallohydrolase activity: X-ray molecular structure, aqua solution behavior and nuclease activity of the complex [Fe(HPClNOL)(SO4)]2-μ-oxo

“…Thus, metal compounds with the following features can be considered of interest to mimic nuclease and peptidase activities: (a) be water soluble to some extent and form cationic species in solution; (b) have an unsaturated coordination environment or labile ligands, which can be replaced In this regard, our research group has developed tripodal tetradendate ligands which when complexed with first row transition metal ions can form coordination compounds with the features established above [6][7][8][9]. Thus, we report herein the crystal structure and water solution behavior of the complex [Fe(HPClNOL)(SO 4 )] 2 -l-oxo 1, which shows all the above mentioned properties of interest for a nuclease/peptidase mimicking compound.…”

Extraction and Spectrophotometric Determination of Copper (Ii) with 1-(2-Metoxiphenylamin)-3-Metoksipropanthiol-2

“…Its antibacterial properties have been known for thousands of years. Synthetic copper(II) complexes have been reported to act as a potential anticancer and cancer inhibiting agents and a number of copper complexes have been found to be active both in vitro and in vivo [3,4]. Therefore it is necessary to control that the content of copper (II) ions in the environmental objects is within the permissible concentrations.…”

Synthesis, characterization, and bioactivities of copper complexes with N-substituted Di(picolyl)amines

“…Recently N-substituted di(picolyl)amines were found to be active against the proliferation of cancer cells [10]. The mononuclear copper(II) complex of 1-(bis-pyridin-2-ylmethyl-amino)-3-chloropropane-2-ol) was reported to promote cell death of THP-1 carcinogenic cells by apoptosis [11]. Here, we report the synthesis, characterization, interaction with DNA, and antitumor activities of Cu(II) complexes with ethyl bis(2-pyridylmethyl)amino-2-propionate (Etdpa) and bis(2-pyridylmethyl)amino-2-propionate (Adpa).…”