Synthesis, crystal structures and anticancer activities of Cu(II), Zn(II) and Cd(II) complexes containing bis(2-pyridyl)-di(4-methoxyphenyl)ethene

Hải, Lê Thị Hồng; Huu, Thinh Nguyen; Anh, Tho Duong; Nhat, Khanh Nguyen; Quoc, Long Pham; Dang, Tuan Thanh; Nguyen, Hien Minh; Meervelt, Luc Van

doi:10.1080/00958972.2022.2051498

Journal of Coordination Chemistry

2022

DOI: 10.1080/00958972.2022.2051498

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Synthesis, crystal structures and anticancer activities of Cu(II), Zn(II) and Cd(II) complexes containing bis(2-pyridyl)-di(4-methoxyphenyl)ethene

Lê Thị Hồng Hải

Thinh Nguyen Huu

Tho Duong Anh

et al.

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2024

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Cited by 4 publications

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Synthesis, structure and anticancer activities of Cd(II), Cu(II) and Pd(II) complexes with 5,7‐dichloro‐8‐hydroxylquinoline‐2‐carboxaldehyde‐4‐chloro‐2‐aminothiophenol

Duong,

Giang,

Ngoc

et al. 2022

Vietnam Journal of Chemistry

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Three new complexes of Cd(II), Cu(II) and Pd(II) with 5,7‐dichloro‐8‐hydroxyquinoline‐2‐carboxaldehyde‐4‐chloro‐2‐aminothiophenol (QNS), that are [Cd(QNS‐1H)Cl] (1), [Cu(QNS‐1H)2] (2) and [Pd(QNS‐1H)Cl] (3), were synthesized. Their structures were determined by ESI‐MS, EDX, IR and 1H NMR spectroscopies. The results showed that in (1) and (3) complexes the ratio of M(II):QNS ligand is 1:1, M(II) is bound to QNS through O, Nquinoline and Nbenzothiazole atoms. In complex (2), Cu(II) is bound to the QNS ligand in the 1:2 ratio through Oquinoline and Nquinoline atoms. The complexes were tested for cell in vitro cytotoxicity on human cancer cells. Complex (1) gives better antitumor activity than the remaining complexes on four cancer lines including KB, Hep‐G2, A549 and MCF‐7. The effect of complex (1) on KB and MCF‐7 is higher than cisplatin, a cancer treatment drug, with IC50 values of 15.01 and 17.94 μM, respectively.

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Synthesis, structure and anticancer activities of Cd(II), Cu(II) and Pd(II) complexes with 5,7‐dichloro‐8‐hydroxylquinoline‐2‐carboxaldehyde‐4‐chloro‐2‐aminothiophenol

Duong,

Giang,

Ngoc

et al. 2022

Vietnam Journal of Chemistry

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show abstract

A review on zinc, cadmium, and mercury complexes with anticancer activity

Saeedian Moghadam,

Emamgholipour,

Foroumadi

et al. 2024

Inorganic Chemistry Communications

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Synthesis, crystal structures, and cytotoxicity against cancer cell lines of metal (Co, Cu, Zn, Cd) complexes containing 1,1′-diaryl-2,2′dipyridylethene derivatives

Nguyen,

Dang,

Mai

et al. 2024

Polyhedron

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Synthesis, crystal structures and anticancer activities of Cu(II), Zn(II) and Cd(II) complexes containing bis(2-pyridyl)-di(4-methoxyphenyl)ethene

Cited by 4 publications

References 32 publications

Synthesis, structure and anticancer activities of Cd(II), Cu(II) and Pd(II) complexes with 5,7‐dichloro‐8‐hydroxylquinoline‐2‐carboxaldehyde‐4‐chloro‐2‐aminothiophenol

Synthesis, structure and anticancer activities of Cd(II), Cu(II) and Pd(II) complexes with 5,7‐dichloro‐8‐hydroxylquinoline‐2‐carboxaldehyde‐4‐chloro‐2‐aminothiophenol

A review on zinc, cadmium, and mercury complexes with anticancer activity

Synthesis, crystal structures, and cytotoxicity against cancer cell lines of metal (Co, Cu, Zn, Cd) complexes containing 1,1′-diaryl-2,2′dipyridylethene derivatives

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