Synthesis, cytotoxicity against human oral cancer KB cells and structure–activity relationship studies of trienone analogues of curcuminoids

Synthesis and evaluation of 1,7-diheteroarylhepta-1,4,6-trien-3-ones as curcumin-based anticancer agents

“…It is worth noting that these two trienones have been isolated from Curcuma longa , the plant with curcumin as its major chemical component. These two natural trienones and a group of trienone analogues with two identical substituted phenyl groups have recently been evaluated by Chuprajob and co-workers for their cytotoxic activity against human oral cancer KB cell line [17]. This study indicated that the 1,7-diphenyl-1,4,6-trien-3-ones are more potent than curcumin towards oral cancer cells.…”

Curcumin analogues inhibit phosphodiesterase-5 and dilate rat pulmonary arteries

“…PDE6 activity was conducted using the procedure previously reported,[14] which has been modified from Huang et al ., 1998 [18]. Twenty‐five millilitres of the following reagents was added to tube: buffer 2, EGTA, PDE6 solution and test samples or control (5% DMSO in buffer).…”

Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives

“…These results are consistent with the results in previous studies, which found that meta-oxygenated phenyl ring is favored for anti-inflammatory and anti-cancer properties' enhancement. 36,37 Surprisingly, apart from oxygenated functionalities, the activity enhancement effect of meta-substitution was also been observed in meta-halogenated analogs. This can be seen in the comparison of compounds 9, 18 and 19, of which compounds 18 and 19, the meta-halogenated analogs displayed much stronger NO inhibitory effect than its meta-unsubstituted analog 9.…”