2018
DOI: 10.1002/aoc.4311
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Synthesis, cytotoxicity and anti‐metastatic properties of new pyridyl–thiazole arene ruthenium(II) complexes

Abstract: A series of novel ruthenium(II)-cymene complexes (1-8) containing substituted pyridyl-thiazole ligands, [Ru(η 6 -p-cymene)(L)Cl]Cl (L = N,N-chelating derivatives), have been synthesized and characterized using elemental analysis, infrared, 1 H NMR and 13 C NMR spectroscopies and mass spectrometry. All these complexes not only display marked cytotoxicity in vitro against three different human cancer cell lines (HeLa, A549 and MDA-MB-231), but also exhibit promising anti-metastatic activity at sub-cytotoxic conc… Show more

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Cited by 5 publications
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“…6 Since the aromatic substituents on the ruthenium complexes are crucial for their biological activity, a number of efforts have been made to synthesize various ruthenium arene complexes with potential anticancer activity. 7 Research on novel anticancer drugs has recently focused on ruthenium complexes bearing nitrogen-containing heterocyclic ligands, especially 1,2,3-triazole derivatives. 7 a ,8 The 1,2,3-triazoles, one of the most important classes of nitrogen-containing heterocycles, have diverse biological activities that include antiviral, antibacterial, antifungal and antitubercular activities and excellent hydrogen donating and accepting ability, and have been applied in medicine and in pharmaceuticals during the past decades.…”
Section: Introductionmentioning
confidence: 99%
“…6 Since the aromatic substituents on the ruthenium complexes are crucial for their biological activity, a number of efforts have been made to synthesize various ruthenium arene complexes with potential anticancer activity. 7 Research on novel anticancer drugs has recently focused on ruthenium complexes bearing nitrogen-containing heterocyclic ligands, especially 1,2,3-triazole derivatives. 7 a ,8 The 1,2,3-triazoles, one of the most important classes of nitrogen-containing heterocycles, have diverse biological activities that include antiviral, antibacterial, antifungal and antitubercular activities and excellent hydrogen donating and accepting ability, and have been applied in medicine and in pharmaceuticals during the past decades.…”
Section: Introductionmentioning
confidence: 99%