Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives

Click Synthesis of Some mono/bis 1,2,3-Triazoles with Ester Linkage and their Microbicidal Activity

“…Afterwards, synthesized target compounds were characterized by various spectral techniques like FTIR, 1 H NMR, 13 C NMR spectroscopy and HRMS. In FTIR spectra, C-H stretching of triazole ring absorbed in the region at 3154-3137 cm -1 .…”

“…The progress of reaction was monitored by readymade silica gel plates (SIL G/UV254, ALUGRAM) and visualization was carried out with ultraviolet lamp. The 1 H NMR spectra and 13 C NMR spectra were recorded on BRUKER AVANCE II 400 MHz spectrometer at 400 MHz and 100 MHz respectively in CDCl3/DMSO-d6. Values of coupling constant (J) were given in Hz.…”

“…H NMR, 13 C NMR, HRMS and screened against four bacterial strains i.e. Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes and two fungal strains i.e.…”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…Pyridines form a class of compounds exhibiting potential activities against a wide range of biological targets [18][19][20]. Its derivatives have been designed and synthesized as therapeutic agents [21][22][23][24], as herbicides, fungicides, pesticides and as fluorescent dyes [25,26].…”

Antimicrobial and Anti-biofilm Activity of Thiourea Derivatives Incorporating a 2-Aminothiazole Scaffold

“…Biofilm Inhibitory Assay Inhibition of bacterial biofilm formation was screened using method, described previously, 39) with some modification. Eight hospital isolates of methicillinresistant and two standard strains of Staphylococcus epidermidis (ATC C 12228, ATC C 35984) were cultured overnight in Tryptone Soy Broth with 0,5% glucose.…”