Synthesis-dependant structural variations in amorphous calcium carbonate

Lam, Raymond S.K.; Charnock, John; Lennie, Alistair R.; Meldrum, Fiona C.

doi:10.1039/b710895h

Cited by 174 publications

(204 citation statements)

References 70 publications

(140 reference statements)

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“…The broad band features a shoulder (~1469 cm −1 ) that could relate to the split band that is normally observed for ACC and could include contributions from amide bands of proteins present in stone. The band for the out-of-plane bending mode (ν 2 ) at 872 cm −1 cannot be used directly to discriminate ACC from crystalline forms of CaCO 3 either, because its position varies for different types of ACC [35][36][37][38][39][40]. However, in this case, the band position agrees with literature reports on calcite [34].…”

Section: Resultssupporting

confidence: 76%

Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation—A Urinary Stone from a Guinea Pig

et al. 2018

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Abstract:Calcium carbonate is an abundant biomineral that is of great importance in industrial or geological contexts. In recent years, many studies of the precipitation of CaCO 3 have shown that amorphous precursors and intermediates are widespread in the biomineralization processes and can also be exploited in bio-inspired materials chemistry. In this work, the thorough investigation of a urinary stone of a guinea pig suggests that amorphous calcium carbonate (ACC) can play a role in pathological mineralization. Importantly, certain analytical techniques that are often applied in the corresponding analyses are sensitive only to crystalline CaCO 3 and can misleadingly exclude the relevance of calcium carbonate during the formation of urinary stones. Our analyses suggest that ACC is the major constituent of the particular stone studied, which possibly precipitated on struvite nuclei. Minor amounts of urea, other stable inorganics, and minor organic inclusions are observed as well.

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Section: Resultssupporting

confidence: 76%

Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation—A Urinary Stone from a Guinea Pig

et al. 2018

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“…It is important to find out why Asp monomer has such an unexpected function. The previous understandings of biomineralization often suggest that polyAsp is an excellent model system to simulate the Asp-rich proteins (33,34). However, Mann et al have demonstrated that the polyAsp with long chain-length greatly inhibits ACP transformation while the extracted protein with similar molecular weight promotes the transformation (40).…”

Section: Resultsmentioning

confidence: 99%

Magnesium-aspartate-based crystallization switch inspired from shell molt of crustacean

Tao

Zhou

Zhang

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

131

124

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Many animals such as crustacean periodically undergo cyclic molt of the exoskeleton. During this process, amorphous calcium mineral phases are biologically stabilized by magnesium and are reserved for the subsequent rapid formation of new shell tissue. However, it is a mystery how living organisms can regulate the transition of the precursor phases precisely. We reveal that the shell mineralization from the magnesium stabilized precursors is associated with the presence of Asp-rich proteins. It is suggested that a cooperative effect of magnesium and Asp-rich compound can result into a crystallization switch in biomineralization. Our in vitro experiments confirm that magnesium increases the lifetime of amorphous calcium carbonate and calcium phosphate in solution so that the crystallization can be temporarily switched off. Although Asp monomer alone inhibits the crystallization of pure amorphous calcium minerals, it actually reduces the stability of the magnesium-stabilized precursors to switch on the transformation from the amorphous to crystallized phases. These modification effects on crystallization kinetics can be understood by an Asp-enhanced magnesium desolvation model. The interesting magnesium-Asp-based switch is a biologically inspired lesson from nature, which can be developed into an advanced strategy to control material fabrications.biomineralization ͉ calcium biominerals ͉ phase transformation

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“…If we consider a solid structure, the molecules within it will not pack as perfect spheres, but will form an atomically rough surface. As a result, if we try to obtain a value of the available volume occupied by water molecules using the Van der Waals radius of water, 1.575 Å (shown in Table 3) we obtain values that are considerably lower than the average volume of a molecule in liquid water (30.0 Å 3 ), or indeed of that reported for a water molecule within monohydrocalcite: 29 14.86 Å 3 . On the other hand, using a probe radius of zero will overestimate the volume (area), as it overlooks the inefficient packing of spheres in 3D space that happens with real atoms and molecules.…”

Section: Water-accessible Volume and Areamentioning

confidence: 99%

“…Hydrated amorphous calcium carbonate is an example of such a phase and is the precursor to calcite (usually) 6 , aragonite 7 and vaterite 8 in many living organisms. Control over structures, polymorph selection and properties is achieved by a complex interplay between the solution chemistry 9 , the presence of inorganic 10,11 or organic [12][13][14] molecules and the physical conditions 15,16 under which the phase precipitates.…”

Section: Introductionmentioning

confidence: 99%

Using simulation to understand the structure and properties of hydrated amorphous calcium carbonate

et al. 2016

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We report results from studies using four different protocols to prepare hydrated amorphous calcium carbonate, ranging from random initial structures to melting hydrated mineral structures.All protocols give good agreement with experimental X-ray structure factors. However, the thermodynamic properties, ion coordination environments, and distribution of water for the structures produced by the protocols show statistically significant variation depending on the protocols used. We discuss the diffusivity of water through the various structures and its relation to experiments. We show that one protocol (based on melting ikaite) gives a structure where the water is mobile, due to the presence of porosity in the amorphous structure. We conclude that our models of hydrated amorphous calcium carbonate do give a range of behaviour that resembles that observed experimentally, although the variation is less marked in the simulations than in experiments.3

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Synthesis-dependant structural variations in amorphous calcium carbonate

Cited by 174 publications

References 70 publications

Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation—A Urinary Stone from a Guinea Pig

Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation—A Urinary Stone from a Guinea Pig

Magnesium-aspartate-based crystallization switch inspired from shell molt of crustacean

Using simulation to understand the structure and properties of hydrated amorphous calcium carbonate

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