Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines

Naik, T. R. Ravikumar; Naik, H.S. Bhojya; Naik, H. R. Prakash; Bindu, P. J.; Harish, B. S.; Krishna, Vagolu Siva

doi:10.2174/157340609789117804

Cited by 15 publications

(6 citation statements)

References 16 publications

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“…On the other hand, a pleasant experience will make consumers have a high tolerance for the company so that consumers feel satisfied even though the service provided is considered unsatisfactory. This is supported by studies which state that service quality has a positive and significant effect on customer satisfaction in the retail context [7,8].…”

Section: Introductionmentioning

confidence: 71%

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Satisfaction as Mediator in the Relationship between Service Quality and Image to Loyalty in the Retail Business

Andari¹,

Najmudin²,

Harnaji³

2019

Proceedings of the International Conference on Banking, Accounting, Management, and Economics (ICOBAME 2018)

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The purpose of this paper is to examine the relationship between the development of service quality, image, satisfaction, and loyalty to retail business customers in Yogyakarta. The survey was used to look at the relationships by collecting data through questionnaires. The sample was taken from 138 retail business customers in Yogyakarta for 6 months. Furthermore, the data were analyzed using multiple linear regression and hierarchical regression. This study found that service quality and image influence customer satisfaction. Customer satisfaction only mediates the relationship between image and loyalty. This research has implications for marketers that service quality is a variable that cannot be ignored in the retail business to make loyal consumers. But the image is another important consideration for marketers to make consumers loyal to retail.

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Section: Introductionmentioning

confidence: 71%

“…This study is inspired by studies [6,7,9,[16][17][18]. This study emphasizes the empirical analysis of the relationship of service quality, image, customer satisfaction and customer loyalty in the retail industry in Yogyakarta.…”

Section: Research Modelmentioning

confidence: 99%

Satisfaction as Mediator in the Relationship between Service Quality and Image to Loyalty in the Retail Business

Andari¹,

Najmudin²,

Harnaji³

2019

Proceedings of the International Conference on Banking, Accounting, Management, and Economics (ICOBAME 2018)

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“…In view of the above biological importance and in continuation of our previous work 26–28, we demonstrate a new strategy to introduce oxadiazole or thiadiazole or triazole rings into macrocycles employing the novel precursors 1 , 2 and 3 (Fig. 1) without using high dilution conditions.…”

Section: Introductionmentioning

confidence: 80%

Synthesis and Biological Evaluation of New Tetra‐aza Macrocyclic Scaffold Constrained Oxadiazole, Thiadiazole and Triazole Rings

Kumar

Naik

Girija

et al. 2011

Archiv der Pharmazie

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A new series of N,N'-(benzene-1,3-diyldi-1,3,4-oxadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-oxadiazol-2-yl)amino]acetamide}(macrocycle 1), N,N'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide} (macrocycle 2) and S,S'-[benzene-1,3-diylbis(4H-1,2,4-triazole-5,3-diyl)]bis{[(5-benzene-1,3-diyl-4H-1,2,4-triazol-3-yl)sulfanyl]ethanethioate}(macrocycle 3) was synthesized from isophthalic dihydrazide (4) through a multistep reaction sequence. All the synthesized compounds were screened for their inhibitory effect against four different bacterial strains: P. aeruginosa ATCC-20852, K. pneumoniae MTCC-618, S. aureus ATCC- 29737, S. typhi MTCC- 3214. The synthesized compounds showed a significant zone of inhibition and the results were comparable with that of the standard drug ciprofloxacin. The synthesized compounds were further studied for their possible in vitro antioxidant effects by DPPH scavenging, total antioxidant capacity, total reductive capacity and H(2) O(2) scavenging activity. The results indicated that the in vitro antioxidant activity for all the three molecules was efficient when compared to the standards. The DNA interaction behavior of macrocycles 1-3 with CT-DNA was investigated by the absorption spectra obtained (K(b) constant for 1 is 4.53 × 10(4) M(-1) , for 2 is 5.75 × 10(4) M(-1) and for 3 is 5.86 × 10(4) M(-1) ). Based on the results it can be interpreted that the reducing power effect of the newly synthesized compounds demonstrates a direct effect on DNA binding and hence inhibiting the bacterial growth through their action on DNA by inhibiting DNA replication or DNA transcription.

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“…Several organic compounds, bearing quite diverse structures, have been identified as DNA photocleavaging agents. These include [1,2,4]−triazolo−[4,3−a]quinoxalines (33), quinoxalin−4(5 H )−ones (34), enediynes (35,36), pyrrolecarboxamide conjugated 4′−bromo−acetophenones (37), halophenyl sulfonamide derivatives of poly N −methylimidazoles (38), naphthalimides, (39–41) nitrobenzamido amino‐acridine derivatives (42,43), benzo[ b ][1,8]naphthyridines (44) and quinolones (45–47), N −phenylhydroxylamine derivatives (48), O −acyl (49–53), O −sulphonyl (54,55) and O ‐carbamoyl (56) oximes, β−carbolines (57,58), pyrazole derivatives (59,60), azido carbonyl compounds (61), etc.…”

Section: Introductionmentioning

confidence: 99%

6‐Nitro‐Quinazolin−4(3H)−one Exhibits Photodynamic Effects and Photodegrades Human Melanoma Cell Lines. A Study on the Photoreactivity of Simple Quinazolin−4(3H)−ones

Panagopoulos

Balalas

Mitrakas

et al. 2021

Photochem & Photobiology

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Photochemo and photodynamic therapies are minimally invasive approaches for the treatment of cancers and powerful weapons for competing bacterial resistance to antibiotics. Synthetic and naturally occurring quinazolinones are considered privileged anticancer and antibacterial agents, with several of them to have emerged as commercially available drugs. In the present study, applying a single‐step green microwave irradiation mediated protocol we have synthesized eleven quinazolinon−4(3H)−ones, from cheap readily available anthranilic acids, in very good yields and purity. These products were irradiated in the presence of pBR322 plasmid DNA under UVB, UVA and visible light. Four of the compounds proved to be very effective DNA photocleavers, at low concentrations, being time and concentration dependent as well as pH independent. Participation of reactive oxygen species was related to the substitution of quinazolinone derivatives. 6‐Nitro‐quinazolinone in combination with UVA irradiation was found to be in vitro photodestructive for three cell lines; glioblastoma (U87MG and T98G) and mainly melanoma (A−375). Thus, certain appropriately substituted quinazolinones may serve as new lead photosensitizers for the development of promising biotechnological applications and as novel photochemo and photodynamic therapeutics.

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Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines

Cited by 15 publications

References 16 publications

Satisfaction as Mediator in the Relationship between Service Quality and Image to Loyalty in the Retail Business

Satisfaction as Mediator in the Relationship between Service Quality and Image to Loyalty in the Retail Business

Synthesis and Biological Evaluation of New Tetra‐aza Macrocyclic Scaffold Constrained Oxadiazole, Thiadiazole and Triazole Rings

6‐Nitro‐Quinazolin−4(3H)−one Exhibits Photodynamic Effects and Photodegrades Human Melanoma Cell Lines. A Study on the Photoreactivity of Simple Quinazolin−4(3H)−ones

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