Synthesis, DNA interaction and cytotoxicity studies of cis-{[1, 2-bis(aminomethyl)cyclohexane]dihalo}platinum(II) complexes

Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes

“…The resistance factor (RF) values for the given complexes 1 – 8 , defined as the ratio IC 50 (A2780R)/IC 50 (A2780) ranged from 0.59 to 1.14 (S4 Table). These results are comparable with those obtained for the best performing platinum(II) iodido complexes published to date, such as diiodido complexes containing different 1,2-bis(aminomethyl)cyclohexane derivatives, which showed on the same pair of cell lines the resistance factors in the range 1.1–4.1 [35]. Moreover, the RF values obtained for complexes 1 – 8 are lower than for picoplatin (RF = 2.0 as observed in the A2780 and A2780R pair of ovarian carcinoma cell lines used in the present work as well) [36].…”

Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro

“…This diVerence may be explained on the basis of the relationships between the structure and the biologic activity. Some studies reported varying levels of cytotoxicity depending on the structure of the Pt complexes (de Mier-Vinue et al 2008;Vo et al 2010). In fact, a recent review provided a perfect example of how small changes in molecular structure can cause profound diVerences in biological activity (Abu-Surrah et al 2008).…”

Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: New achievements

“…As a blank, a solution in TE of free native DNA was used. The reactions were run at 37°C for 24 h in the dark and the spectra registered in the 220-330 nm range [32].…”