2021
DOI: 10.1002/jssc.202100474
|View full text |Cite
|
Sign up to set email alerts
|

Synthesis, enantioseparation, and absolute configuration assignment of iminoflavans by chiral high‐performance liquid chromatography combined with online chiroptical detection

Abstract: Four racemic iminoflavan derivatives were synthesized by simple condensation at C-4 position of flavanone. All new compounds were characterized by using ultraviolet-visible, infrared, and nuclear magnetic resonance spectroscopic techniques. A chiral chromatographic analysis of racemic mixtures was performed by direct chiral high-performance liquid chromatography using Chiralcel R OD-H as chiral stationary phase, and online-coupled with electronic circular dichroism detector. The correlation of experimental ele… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
4
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4
1

Relationship

2
3

Authors

Journals

citations
Cited by 5 publications
(5 citation statements)
references
References 32 publications
0
4
0
Order By: Relevance
“…Rabeprazole sodium was United States Pharmacopoeia (USP) reference standard (Rockville, USA). Imino avane derivatives were synthesized as described earlier [31,32]. The structure of investigated compounds is depicted in Fig.…”
Section: Methodsmentioning
confidence: 99%
“…Rabeprazole sodium was United States Pharmacopoeia (USP) reference standard (Rockville, USA). Imino avane derivatives were synthesized as described earlier [31,32]. The structure of investigated compounds is depicted in Fig.…”
Section: Methodsmentioning
confidence: 99%
“…For many years, our research laboratory was directed toward organic synthesis, the study of the biological activities of the synthesized compounds and their chiral separation using different chromatographic methods. [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] Finally, a new bioactive compound was synthesized. The synthesis was carried out in two steps, that is, by producing an intermediate compound (I) followed by adding isothiocyanate as a key element.…”
Section: Introductionmentioning
confidence: 99%
“…For many years, our research laboratory was directed toward organic synthesis, the study of the biological activities of the synthesized compounds and their chiral separation using different chromatographic methods 28–43 . Finally, a new bioactive compound was synthesized.…”
Section: Introductionmentioning
confidence: 99%
“…Over the last decade, many analytical and preparative chromatographic and electrophoretic methods (mainly HPLC and capillary electrophoresis (CE)) have been developed to study the biological action and activity of enantiomeric drugs. Among the methods currently used to achieve chiral separation of racemic mixtures, high-resolution chromatographic systems based on chiral stationary phases (CSPs) (direct methods) are more rapid and suitable for racemic mixtures [14][15][16][17].…”
Section: Introductionmentioning
confidence: 99%