In this letter, computer-aided design models based on adaptive-network-based fuzzy inference system (ANFIS) for the synthesis of two coplanar stripline structures are presented. These coplanar stripline structures are micro-coplanar stripline and asymmetric coplanar stripline with an infinitely wide strip. Four optimization algorithms, hybrid learning (HL), simulated annealing, least-squares, and genetic, are used to determine optimally the design parameters of the ANFIS models. The results of ANFIS models are compared with the results of quasi-static analysis, synthesis formulas available in the literature, a full-wave electromagnetic simulator IE3D, and experimental works realized in this study. The results of ANFIS models agree with the results of other methods and experimental works. When the performances of ANFIS models are compared with each other, the best results for training and test are obtained from the models trained with HL algorithm.