Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi, Jalal; Kiyasatfar, Mehdi; Laurent, Sophie

doi:10.1002/adhm.201700306

Cited by 204 publications

(188 citation statements)

References 1,066 publications

(798 reference statements)

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“…The nanobiotechnology is promisingly based on the eco-friendly and green routes [6,7]. The biogenic routes have considered as leading paths to get the desired product having a specific shape, size, and surface chemistry, which are still challengeable in the chemical routes [8,9]. The synthesis of noble metal NPs using plant extract as a reducing agent is advancing the topic due to their remarkable applications in medicine sector [10,11].…”

Section: Introductionmentioning

confidence: 99%

Flacourtia indica based biogenic nanoparticles: development, characterization, and bioactivity against wound associated pathogens

Ahmad

Taj

Ramzan

et al. 2020

Mater. Res. Express

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Surface engineered nanoparticles (NPs) are of great attention due to their targeted medical applications. The nature of the functionalized surface plays a vital role in achieving the required functionalities of engineered NPs. Owing to the biofilm formation capabilities of wound associated pathogens, impaired wound healing is a major complication in the medical field. In this context, herein, we report the biogenic synthesis of Flacourtia indica (FI) based NPs, i.e., FI-AgNPs using the aqueous leaf extract of this anti-bacterial herb. The newly developed FI-AgNPs were characterized using various analytical and imaging techniques such as UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The FI-AgNPs showed potent anti-microbial activity and anti-biofilm potential which were examined through a test tube adherence method and congo red agar method. It has been observed that synthesized FI-AgNPs inhibit the formation of a biofilm of observed bacteria, even at a minimum concentration of 80 μgml −1 . These findings suggest that synthesized FI-AgNPs could be used against wound associated microbes, especially bacterial coating on medical devices, to prevent antibiotic-resistant biofilm infections. Further development and research are obligatory to decode this skill into preventive and therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

Flacourtia indica based biogenic nanoparticles: development, characterization, and bioactivity against wound associated pathogens

Ahmad

Taj

Ramzan

et al. 2020

Mater. Res. Express

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“…These particles have large magnetic moments and are widely used as T2 contrast agents in MRI. T2 agents alter the transverse relaxation times (T2) of water protons and provide dark negative signal intensity in images [5].…”

Section: Biomedical Applications Of Spionsmentioning

confidence: 99%

Toxicity assessment of superparamagnetic iron oxide nanoparticles in different tissues

Vakili‐Ghartavol

Momtazi‐Borojeni

Vakili-Ghartavol

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

134

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been employed in several biomedical applications where they facilitate both diagnostic and therapeutic aims. Although the potential benefits of SPIONs with different surface chemistry and conjugated targeting ligands/proteins are considerable, complicated interactions between these nanoparticles (NPs) and cells leading to toxic impacts could limit their clinical applications. Hence, elevation of our knowledge regarding the SPION-related toxicity is necessary. Here, the present review article will consider current studies and compare the potential toxic effect of SPIONs with or without identical surface chemistries on different cell lines. It centers on cellular and molecular mechanisms underlying toxicity of SPIONs. Likewise, emphasis is being dedicated for toxicity of SPIONs in various cell lines, in vitro and animal models, in vivo.

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“…Furthermore, numerous studies have reported that patients with PCa receiving neural drugs (-blockers) are at a decreased risk of recurrence and mortality (33)(34)(35). Thus, the drug-loading properties of the nanoprobe (36,37) were harnessed to load a neural drug serving as a nerve blocker in PCa, thus facilitating interventions in PCa with high nerve density and improving nanoprobe effectiveness and usability. Together, we exploited a nanoprobe that enabled not only visualization of nerve density but also targeting delivery of neural drug to inhibit tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer

et al. 2020

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Nerve density is associated with prostate cancer (PCa) aggressiveness and prognosis. Thus far, no visualization methods have been developed to assess nerve density of PCa in vivo. We compounded propranolol-conjugated superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs), which achieved the nerve density visualization of PCa with high sensitivity and high specificity, and facilitated assessment of nerve density and aggressiveness of PCa using magnetic resonance imaging and magnetic particle imaging. Moreover, PSN NPs facilitated targeted therapy for PCa. PSN NPs increased the survival rate of mice with orthotopic PCa to 83.3% and decreased nerve densities and proliferation indexes by more than twofold compared with the control groups. The present study, thus, developed a technology to visualize the nerve density of PCa and facilitate targeted neural drug delivery to tumors to efficiently inhibit PCa progression. Our study provides a potential basis for clinical imaging and therapeutic interventions targeting nerves in PCa.

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Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Cited by 204 publications

References 1,066 publications

Flacourtia indica based biogenic nanoparticles: development, characterization, and bioactivity against wound associated pathogens

Flacourtia indica based biogenic nanoparticles: development, characterization, and bioactivity against wound associated pathogens

Toxicity assessment of superparamagnetic iron oxide nanoparticles in different tissues

Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer

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