Synthesis, hydroxyl radical production and cytotoxicity of analogues of bleomycin

Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety

“…Moreover, some pyridothienotriazines are known to exhibit antianaphylactic [11] and antiallergic activity [12]. In view of these facts and as a continuation of our previous work [13,[14][15][16][17][18][19], we report herein the synthesis of new compounds bearing both pyridine, thienopyrimidine, pyrazolo [1,5-a]pyrimidine, [1,2,4]triazolo [1,5-a]pyrimidine and pyrimido [1,2-a]benzimidazole with the objective of obtaining new biologically active compounds.…”

“…IR spectra were recorded (KBr discs) on a Shimadzu FT-IR 8201 PC spectrophotometer. 1 H and 13 C NMR spectra were recorded in CDCl3 and (CD3)2SO solutions on a Varian Gemini 300 MHz spectrometer and chemical shifts are expressed as δ ppm using TMS as an internal reference. Mass spectra were recorded on a GC-MS QP 1000 EX Shimadzu.…”

“…Pyridine derivatives are widely applied in medicine and agriculture, for example, used as anticancer [1], anti-hypertension [2] and antifungal [3], pesticides [4], herbicides [4], plant growth reagents [4] etc. Several thieno [2,3-b]pyridine derivatives are known to possess antibacterial [5], antihypertensive [6] and gonadotropinreleasing hormone antagonizing [7,8] activity.…”

Crystal structure of 6-(4-chlorophenoxy)-1-methylindoline-2,3-dione, C15H10CINO3

“…1,2,4-triazole derivatives possess potent biological activities such as pesticidal [2], antibacterial [3], and antifungal [4]. Difenoconazole is important representative of this class, which has been used as the most efficient triazole fungicide in the control of somec ommonp lant diseases [5].B ut al ot of waste residues are formed in the process of production.…”

Spectroscopic, Thermal and Biological Studies of Zn(II), Cd(II) and Hg(II) Complexes Derived from 3-Aminopyridine and Nitrite Ion

“…5 The heterocyclic compounds, containing N-donor ligand system like 3-aminopyridine (3AP), play a significant role in many biological systems, being a component of several vitamins and drugs. 6,7 Pyridine derivatives are widely applied in medicine as anticancer, 8 anti-hypertension and antifungal agents.…”