2023
DOI: 10.1080/14756366.2023.2205042
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Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Samuel T. Boateng,
Tithi Roy,
Kara Torrey
et al.

Abstract: Twenty-five azole compounds ( P1 – P25 ) were synthesised using regioselective base-metal catalysed and microwave-assisted approaches, fully characterised by high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), and infrared spectra (IR) analyses, and evaluated for anticancer, anti-tyrosinase, and anti-oxidant activities in silico and in vitro . P25 exhibited potent anticance… Show more

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Cited by 9 publications
(3 citation statements)
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“…After the solvent evaporated and solid precipitation occurred, appropriate sections of the paper device were cut out and placed in CDCl 3 to extract the reaction products. These product-containing solutions were then analyzed with 1 H NMR spectroscopy (Varian 400 MHz-NMR, Palo Alto, CA, USA), demonstrating the successful synthesis and efficient product separation of reactions on the paper device. , The quantities of 5-methyl-3-phenyl-1 H -pyrazole ( 4 ) and 3,5-diphenylpyrazole ( 5 ) products were determined to be 0.13 and 0.15 mg, respectively.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…After the solvent evaporated and solid precipitation occurred, appropriate sections of the paper device were cut out and placed in CDCl 3 to extract the reaction products. These product-containing solutions were then analyzed with 1 H NMR spectroscopy (Varian 400 MHz-NMR, Palo Alto, CA, USA), demonstrating the successful synthesis and efficient product separation of reactions on the paper device. , The quantities of 5-methyl-3-phenyl-1 H -pyrazole ( 4 ) and 3,5-diphenylpyrazole ( 5 ) products were determined to be 0.13 and 0.15 mg, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…These product-containing solutions were then analyzed with 1 H NMR spectroscopy (Varian 400 MHz-NMR, Palo Alto, CA, USA), demonstrating the successful synthesis and efficient product separation of reactions on the paper device. 37,38 The quantities of 5-methyl-3-phenyl-1H-pyrazole (4) and 3,5diphenylpyrazole (5) products were determined to be 0.13 and 0.15 mg, respectively.…”
Section: Simultaneous Reaction and Separation Of Multiple Productsmentioning
confidence: 99%
“…Melanin polymers are high-molecular-weight pigments known for protecting the skin against the deleterious effects of UV rays. Many natural tyrosinase inhibitors, such as kojic acid, azelaic acid, hydroquinone, arbutin, and numerous phenolic compounds, are prospectively safer, more efficacious treatments for malignant neoplasms and can reduce excessive melanin production [8]. In this same context, plant EOs have attracted great interest as therapeutic active compounds and have been explored as inhibitors of tyrosinase [9,10].…”
Section: Introductionmentioning
confidence: 99%