Synthesis, in vitro Antibacterial and in vivo Anti-Inflammatory Activity of Some New Pyridines

New Heterocyclic Compounds Derived from 4,6‐Diamino‐3‐cyano‐2‐methylthiopyridine and their Biological Activity

“…A number of heterocyclic compounds containing pyridine ring possess a broad spectrum of biological activities such as: anti-inflammatory [3,4], antibacterial [5,6], antifungal [7,8], anticancer [9,10], antidiabetic [11], antiviral [12,13], antidote [14], antioxidant [15], antichagasic [16], and along with most of the traditional biological activities. In view of these findings and in continuation of our previous work [17][18][19] we report herein synthesis of some new pyridine derivatives and tested for anti-inflammatory and antifungal activity.…”

“…13 C NMR spectra of compounds 11, 13, and 15 showed a new signals corresponding to C¼O groups at 197.66, 203.32, 166.83, and 163.02 ppm, respectively. Treatment of butanamide 13 with appropriate aromatic and heterocyclic diazonium salts of p-toluidine, p-chloroaniline, 3-aminopyridine, or 2-aminothiadiazole in pyridine yielded the corresponding arylhydrazones [16][17][18][19]. 1 H NMR spectrum of compound 17 showed the absence of one signal corresponding to CH 2 group, while exhibiting signal corresponding to NH group at 13.80 ppm as singlet.…”

Multicomponent Reaction for Synthesis of Novel 2‐Tosyloxyphenylpyridines

“…In view of these findings and in continuation of our previous work [20][21][22][23][24][25], we reported herein a simple, rapid, and high-yielding multicomponent reaction protocol for the synthesis of 2-tosyloxyphenylpyridine derivatives 5 and 8-17.…”

New Route for the Synthesis of Hetaryl‐1,5‐benzodiazepines: Part 2

“…Compound 2 was subjected to react with active halo compounds, namely, ethyl bromoacetate, chloroacetonitrile, phenacyl bromide, 3‐bromopentane‐2,4‐dione, or 1‐bromo‐1‐(phenyldiazenyl) acetone in presence of piperidine as a catalyst to yield the corresponding: 3‐[(5‐oxo‐1,4,5,6‐tetrahydro‐1,2,4‐triazin‐3‐yl)thio]‐, 3‐[(5‐amino‐1,6‐dihydro‐1,2,4‐triazin‐3‐yl)thio]‐, 3‐[(5‐phenyl‐1,6‐dihydro‐1,2,4‐triazin‐3‐yl)‐thio]‐, 3‐[(5‐methyl‐1,6‐dihydro‐1,2,4‐triazin‐3‐yl)thio]‐, and 3‐[(5‐methyl‐6‐phenyl‐diazene‐1,2,4‐triazin‐3‐yl)thio]‐1,5‐benzodiazepin‐2‐ones 4 – 8 , respectively (Scheme ). The reaction pathway was assumed to proceed via the N‐NH 2 group alkylation followed by a nucleophilic attack of another amino group at carbonyl group with elimination of ethanol molecule to give compound 4 or water molecule to form compounds 6 – 8 or at the cyano group to give compound 5 ; deacetylation has occurred in case of compound 7 . The IR spectra of compounds 4 – 8 showed the disappearance of the absorption bands corresponding to the two amino groups, while exhibiting new bands corresponding to NH at 3342–3150 cm −1 and C=O at 1686–1635 cm −1 .…”