2022
DOI: 10.1016/j.compbiolchem.2022.107641
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Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives

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Cited by 4 publications
(1 citation statement)
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“…Moreover, the pyrazole and indolin‐2‐one based compounds have presented extensive biological properties, such as antitumoral, [7,8,9,10] anti‐inflammatory, [11] and antimicrobial activities [11,12,13] . Similarly the 2‐oxindole derivatives have been previously described as cytotoxic, [14,15] antimicrobial, [16] antiviral, [17] Ligase‐1 [18] and BCL 2 inhibitors, [19,20] and as anticancer agents [21,22] (Figure 1). The objective of the present investigation was to synthesize and characterize pyrazoles with 2‐oxindole conjugates ( 6a – 6k ) as anti‐cancer agents.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the pyrazole and indolin‐2‐one based compounds have presented extensive biological properties, such as antitumoral, [7,8,9,10] anti‐inflammatory, [11] and antimicrobial activities [11,12,13] . Similarly the 2‐oxindole derivatives have been previously described as cytotoxic, [14,15] antimicrobial, [16] antiviral, [17] Ligase‐1 [18] and BCL 2 inhibitors, [19,20] and as anticancer agents [21,22] (Figure 1). The objective of the present investigation was to synthesize and characterize pyrazoles with 2‐oxindole conjugates ( 6a – 6k ) as anti‐cancer agents.…”
Section: Introductionmentioning
confidence: 99%