2022
DOI: 10.15826/chimtech.2023.10.1.02
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Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

Abstract: A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was foun… Show more

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Cited by 2 publications
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“…The focus of this study is on the synthesis of hybrid molecules based on furan-2(3H)ones and 4-oxo-4H-chromene-3-carbaldehyde. Furan-2(3H)-one derivatives are found among a large number of compounds that have antinociceptive, anti-inflammatory, antiviral and antitumor effects [14][15][16][17]. It is important to note nitrofuran derivatives, which have pronounced antibacterial activity [18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…The focus of this study is on the synthesis of hybrid molecules based on furan-2(3H)ones and 4-oxo-4H-chromene-3-carbaldehyde. Furan-2(3H)-one derivatives are found among a large number of compounds that have antinociceptive, anti-inflammatory, antiviral and antitumor effects [14][15][16][17]. It is important to note nitrofuran derivatives, which have pronounced antibacterial activity [18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%