Synthesis, micellization, and thermally-induced macroscopic micelle aggregation of poly(vinyl chloride)-g-poly(N-isopropylacrylamide) amphiphilic copolymer

Abstract

PVC-g-PNIPAM amphiphilic copolymers with controlled graft lengths and densities are synthesized, which form unique macroscopic aggregates with well-defined 3D shapes in dilute aqueous solution above the LCST.

Recent Developments in the Synthesis of Biomacromolecules and their Conjugates by Single Electron Transfer–Living Radical Polymerization

“…Since the pioneer work of Monteiro and co-workers, SET-LRP has been proven to be an outstanding tool for the precise preparation of a variety of amphiphilic block copolymers with different architectures with, in some cases, promising applications. ,,,,,,,− Taking advantage of SET-LRP, Monteiro and co-workers reported the preparation of linear and 4-armed star copolymers composed of MA and SA . The subsequent deprotection of the solketal side chains produced amphiphilic copolymers that self-assembled in water into micellar and vesicular structures.…”

Internal plasticization of poly(vinyl chloride) by grafting acrylate copolymers via copper‐mediated atom transfer radical polymerization

“…A T g value of − 19°C was achieved with 65 mol% of PBA grafts. Several research groups have utilized activated chlorines at PVC defect sites to prepare PVC‐graft copolymers by ATRP 38–48 . These defect sites include both allylic and tertiary chlorides (Figure 1).…”

“…Several research groups have utilized activated chlorines at PVC defect sites to prepare PVC-graft copolymers by ATRP. [38][39][40][41][42][43][44][45][46][47][48] These defect sites include both allylic and tertiary chlorides (Figure 1). 49 Estimates of allylic chloride content ranges from 0.05-0.72/1000 vinyl chloride units, 50,51 and tertiary chloride content from 0.7-2.1/1000 vinyl chloride units.…”

Thermoresponsive 2-hydroxy-3-isopropoxypropyl hydroxyethyl cellulose with tunable LCST for drug delivery

“…The thermoresponsive drug delivery systems, if properly designed, can realize controlled release in very mild conditions even in the physiological temperature range. 6,[12][13][14] Typical studies have focused on block copolymers containing poly(N-isopropylacrylamide) and poly(alkylene oxide) functional units. These thermoresponsive copolymers can self-assemble into stable spherical micelles or cylindrical aggregates in the appropriate temperature range.…”