Synthesis, microstructure, and mechanical behaviour of a unique porous PHBV scaffold manufactured using selective laser sintering

Diermann, Sven H.; Lu, Minghui; Zhao, Yitian; Vandi, Luigi‐Jules; Dargusch, Matthew S.; Huang, Han

doi:10.1016/j.jmbbm.2018.05.007

Cited by 51 publications

(37 citation statements)

References 36 publications

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“…It was found that all scaffolds had a higher normal compressive strength than lateral strength, while having a higher lateral compressive modulus than normal modulus. In our previous study, scaffolds with similar relative densities showed a contrary moduli‐relation; the normal moduli of the PHBV scaffolds were higher than the lateral moduli. This disagreement is likely related to the difference in layer thickness (20 μm) applied in the two studies.…”

Section: Discussionmentioning

confidence: 79%

“…We have previously proposed a concept of intralayer density gradients (ILDG) in highly porous microstructures manufactured using SLS. In brief, the ILDG concept describes the gradient of fused material along the building direction in one deposited layer, as well as the connections to adjacent layers . Due to the reduction in layer thickness in this study, the volume of the powder that was subjected to laser‐induced fusion was reduced.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, PHBV and PHBV/AKM composite scaffolds with a unique porous microstructure were successfully manufactured using SLS. The SLS processing parameters were optimized for the PHBV/AKM composite powder, based on the results obtained from our previous study . The part bed temperature was increased by 15 to 140°C, and the layer thickness was reduced from 0.1 to 0.08 mm, to minimize the quantity of loose powder particles trapped inside the scaffolds and to create stronger interlayer bonding.…”

Section: Discussionmentioning

confidence: 99%

“…Scaffolds were fabricated using a DTM Sinterstation 2500 Plus SLS system (3D Systems, USA). A mechanical system that integrated smaller powder feeds and a smaller part build platform was designed and adapted into the SLS machine to minimize the usage of powder for the manufacture of small‐scale specimens . Scaffolds in the form of a cube ( L × W × H = 10 × 10 × 10 mm 3 ) were manufactured.…”

Section: Methodsmentioning

confidence: 99%

“…The areal skeleton ( l m ) and pore ( l p ) size in the normal and lateral cross‐sections was determined using a line intersection method, and a weighted average length (

{\overset{false¯}{l}}_{m}

{\overset{false¯}{l}}_{p}

) was calculated accordingly. The details of the intersection method can be found in reference . For each sample set (eight samples in total), five normal and lateral cross‐sections were obtained.…”

Section: Methodsmentioning

confidence: 99%

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Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Diermann

Dargusch

et al. 2019

J Biomed Mater Res

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Scaffold assisted tissue engineering presents a promising approach to repair diseased and fractured bone. For successful bone repair, scaffolds need to be made of biomaterials that degrade with time and promote osteogenesis. Compared to the commonly used ß‐tricalcium phosphate scaffolds, Akermanite (AKM) scaffolds were found to degrade faster and promote more osteogenesis. The objective of this study is to synthesize AKM micro and nanoparticle reinforced poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate; PHBV) composite scaffolds using selective laser sintering (SLS). The synthesized composite scaffolds had an interconnected porous microstructure (61–64% relative porosity), large specific surface areas (31.1–64.2 mm−1) and pore sizes ranging from 303 to 366 and 279 to 357 μm in the normal and lateral direction, respectively, which are suitable for bone tissue repair. The observed hydrophilic nature of the scaffolds and the swift water uptake was due to the introduction of numerous carboxylic acid groups on the scaffold surface after SLS, circumventing the need for postprocessing. For the composite scaffolds, large amounts of AKM particles were exposed on the skeleton surface, which is a requirement for cell attachment. In addition, the particles embedded inside the skeleton helped to significantly reinforce the scaffold structure. The compressive strength and modulus of the composite scaffolds were up to 7.4 and 103 MPa, respectively, which are 149 and 197% of that of the pure PHBV scaffolds. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2596–2610, 2019.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The areal skeleton ( l m ) and pore ( l p ) size in the normal and lateral cross‐sections was determined using a line intersection method, and a weighted average length (

{\overset{false¯}{l}}_{m}

{\overset{false¯}{l}}_{p}

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Diermann

Dargusch

et al. 2019

J Biomed Mater Res

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Laser‐Based Selective Material Processing for Next‐Generation Additive Manufacturing

Park,

Bui

et al. 2023

Advanced Materials

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The connection between laser‐based material processing and additive manufacturing is quite deeply rooted. In fact, the spark that started the field of additive manufacturing was the idea that two intersecting laser beams could selectively solidify a vat of resin. Ever since, laser has been accompanying the field of additive manufacturing, with its repertoire expanded from processing only photopolymer resin to virtually any material, allowing liberating customizability. As a result, additive manufacturing is expected to take an even more prominent role in the global supply chain in years to come. Herein, an overview of laser‐based selective material processing is presented from various aspects: the physics of laser‐material interactions, the materials currently used in additive manufacturing processes, the system configurations that enable laser‐based additive manufacturing, and various functional applications of next‐generation additive manufacturing. Additionally, current challenges and prospects of laser‐based additive manufacturing are discussed.This article is protected by copyright. All rights reserved

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Bioprinting a cell‐laden matrix for bone regeneration: A focused review

Ghorbani

Zhong

et al. 2020

J of Applied Polymer Sci

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Although many efforts have been made to regenerate the bone lesions, existing challenges can be mitigated through the development of tissue engineering scaffolds. However, the weak control on the microstructure of constructs, limitation in preparation of patient-specific and multilayered scaffolds, restriction in the fabrication of cell-laden matrixes, and challenges in preserving the drug/growth factors' efficacy in conventional methods have led to the development of bioprinting technology for regeneration of bone defects. So in this review, conventional 3D printers are classified, then the priority of the different types of bioprinting technologies for the preparation of the cell/growth factor-laden matrixes are focused. Besides, the bio-ink compositions, including polymeric/hybrid hydrogels and cell-based bio-inks are classified according to fundamental and recent studies. Herein, different effective parameters, such as viscosity, rheological properties, cross-linking methods, biodegradation biocompatibility, are considered. Finally, different types of cells and growth factors that can encapsulate in the bio-inks to promote bone repair are discussed, and both in vitro and in vivo achievement are considered. This review provides current and future perspectives of cell-laden bioprinting technologies. The restrictions and challenges are identified, and proper strategies for the development of cell-laden matrixes and high-performance printable bio-inks are proposed.

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Synthesis, microstructure, and mechanical behaviour of a unique porous PHBV scaffold manufactured using selective laser sintering

Cited by 51 publications

References 36 publications

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Laser‐Based Selective Material Processing for Next‐Generation Additive Manufacturing

Bioprinting a cell‐laden matrix for bone regeneration: A focused review

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