Synthesis, molecular modeling, and pharmacological evaluation of new 2-substituted benzoxazole derivatives as potent anti-inflammatory agents

Angajala, Gangadhara; Subashini, R.

doi:10.1007/s11224-019-01374-1

Cited by 21 publications

(13 citation statements)

References 36 publications

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“…Results were compared with standard vancomycin. Studies revealed that compounds 4-(benzoxazol-2-yl)-N-(2-chlorobenzylidene)aniline (26) and 4-(benzoxazol-2-yl)-N-(3,4-dimethoxybenzylidene) aniline (27) exhibit excellent antibacterial activity against strains E coli and S aureus with inhibition zone 25 and 22 mm, respectively. Remaining compounds showed good to mild activity.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthetic transformations and biological screening of benzoxazole derivatives: A review

Sattar

Mukhtar

Atif

et al. 2020

Journal of Heterocyclic Chem

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The presence of benzoxazole moiety in most of the heterocyclic compounds is well reported. The present literature review mainly highlights the novel synthetic transformation and describes the biological potential of most of the heterocyclic compounds by virtue of presence of benzoxazole framework. Most of the researchers have revealed that benzoxazole derivatives exhibit significant antibacterial, anti-inflammatory, antifungal, anticancer, analgesic, antiviral, anti-tubercular, and anthelmintic activities. Benzoxazole moieties also act as tyrosinase inhibitor and cholesterol ester transfer protein inhibitor. This literature review may provide an opportunity to the chemists to design new derivatives of benzoxazole that proved to be the successful agent in view of safety, effectiveness, and efficacy.

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Section: Antibacterial Activitymentioning

confidence: 99%

Synthetic transformations and biological screening of benzoxazole derivatives: A review

Sattar

Mukhtar

Atif

et al. 2020

Journal of Heterocyclic Chem

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“…Benzoxazole represents an important building block for the synthesis of biologically active drug molecules due to its ability to exhibit the desirable pharmacological activities. [6][7][8][9][10][11] Numerous reports have shown that both synthetic as well as naturally occurring compounds with benzoxazole moiety are biologically active against various diseases. In recent times, much progress has been made to develop benzoxazole derivatives into clinical candidates.…”

Section: Introductionmentioning

confidence: 99%

A Patent Review on the Current Developments of Benzoxazoles in Drug Discovery

Wong

Yoon

2021

ChemMedChem

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“…Its aromaticity makes it relatively stable, although as a heterocyclic, it has reactive sites which allow for functionalization8. Benzoxazole displays diverse pharmacological properties including antimicrobial [9][10][11][12][13][14] , multidrug resistant cancer cell activities [15][16] , antiinflammatory [17][18][19] , anticonvulsant 20 , antidepressant 21 , anti-HIV [22][23] , Antihypertensive 24 , anthelmintic 25 activities.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

IJPSR

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Benzoxazole and its analogues play an important role as therapeutic agents and exhibit good cytotoxic as well as antimicrobial activity. In the present study, benzoxazole analogues have been prepared by synthetic route; their spectroscopic evaluation was carried out, and then the synthesized compounds were screened for their cytotoxic activity by Allium cepa root model as well as antimicrobial activity by cup plate method. The synthesis and cytotoxic activity of a novel series of Schiff's base was carried out by reacting the amino group of the 4-Benzoxazol-2yl-phenylamine with different aromatic/ heteroaromatic aldehydes in the presence of polyphosphoric acid to give 4-(1,3-Benzoxazol-2-yl)phenyl]-1-(Substituted phenyl) methanimine (4a-4h) also Diazotization reaction of (4-Benzoxazol-2-yl phenyl) with β napthol gave 2- ((4-(benzo [d]oxazole-2-yl)phenyl) diazenyl) naphthalene-2-ol (4i). The cytotoxic and antimicrobial activities of the synthesized compounds were determined by using the onion root model and cup plate method, respectively. The activity data of compounds was compared with standard drugs Cefixime for antibacterial activity and miconazole for antifungal was used as a standard, and cyclophosphamide was used as a standard for Cytotoxic activity.

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Synthesis, molecular modeling, and pharmacological evaluation of new 2-substituted benzoxazole derivatives as potent anti-inflammatory agents

Cited by 21 publications

References 36 publications

Synthetic transformations and biological screening of benzoxazole derivatives: A review

Synthetic transformations and biological screening of benzoxazole derivatives: A review

A Patent Review on the Current Developments of Benzoxazoles in Drug Discovery

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