Synthesis, molecular structure and solution chemistry of the iridium(III) complex imidazolium [trans(bisimidazole)tetrachloro iridate(III)] (IRIM)

New Chlorido(dimethyl sulfoxide)iridium(III) Complexes with N6‐Substituted Adenines – Kinetic N(7) versus Thermodynamic N(9) Coordinated Adenine Isomers

“…Finally, the cis angles around the metal ion vary between 90.27(3) and 92.55(3)°for 1, 90.00 (12) and 92.55(3)°for 2 and 89.10(10) and 92.47(10)°for 5, while the trans angles are between 176.969(11) and 178.07(1)°for 1, 176.89 (11) and 177.77(12)°for 2 and 175.87(9) and 176.33(6)°for 5. Selected bond lengths and angles are shown in Table 1.…”

“…[16][17][18] Moreover, several Ir III -and Rh III -related compounds have proved to be potent in vitro cytotoxic agents, [19,20] although similar "NAMI-A"-Ir III or Rh III complexes have been found to be inactive, [11,12,21] which has been related to the lack of lability for ligand substitution and redox properties of the metal centre. In this way, the more inert Ir III compounds could be useful as trace systems to study the route of Ru III analogues or designed complexes to deliver an active ligand to a specific receptor.…”

“…Cl 4 -(DMSO-κS){H-AdeC 3 -κN(9)}] (5) are shown in Figure 1. These three zwitterionic inner-sphere complexes present a distorted octahedral geometry around the Ir III metal ion, where the basal plane is occupied by four chlorido ligands and the axial positions by a DMSO ligand coordinated through S (κS) and the corresponding N 6 -substituted adenine [coordinated through N(7) in complexes 1 and 2b and through N (9) plexes of Ru III [17,22,23] and Ir III [11,12] already described. The same can be said for the Ir-Cl bond lengths [ranging from 2.3382(6) to 2.3618(7) Å for 1, 2.340(3) to 2.356(3) Å for 2b and 2.344(3) to 2.358(1) Å for 5].…”

“…[5,6] Furthermore, although several organometallic Ir III compounds with ligands of biological interest have been described, [7][8][9][10] few studies of non-organometallic Ir III complexes have been reported. [11][12][13][14][15] On the other hand, Ru III pleted by the N 6 -substituted adenine molecule. Two different coordination modes are observed: (i) the ligand is protonated at N(1) and coordinated through N(7) (complexes 1-4); (ii) the adenine is protonated at N(3) and coordinated through N(9) (complexes 5-8).…”

Synthesis and in vitro antitumor activity of novel iridium(III) complexes with enantiopure C2-symmetrical vicinal diamine ligands

“…These findings are consistent with the general assumption that the extreme inertness of these iridium(III) complexes is correlated with an absence of cytotoxic effects on human tumor cell lines. [8][9][10] However, recent studies have demonstrated that some trichloridoiridium(III) polypyridyl complexes [11][12][13] and organometallic iridium(III) complexes containing negatively charged pentamethylcyclopentadienyl ligand [14][15][16][17][18][19][20][21][22] have shown promising anticancer activity. Additionally, a review has summarized recent work using iridium(III) complexes as anticancer drugs, focusing on the cytotoxic activity, cellular uptake efficiency, and mechanisms of these complexes.…”