Synthesis, nematicidal evaluation, and SAR study of benzofuran derivatives containing 2-carbonyl thiophene

Synthesis, Nematicidal Evaluation, and the Structure–Activity Relationship Study of Aurone Derivatives

“…7,8 Up to now, only few new nematicides have been used in the market or been registered (Figure 1). 6,9,10 Although the biological control strategy for nematodes has received more attention, chemical nematicides are still the main means at present. New chemical nematicides are required to meet the huge market demands and control the growing resistance.…”

“…However, with increasing concerns about food safety, toxicity to non-target organisms, and environmental pollution, highly toxic nematicides are gradually being eliminated. , Up to now, only few new nematicides have been used in the market or been registered (Figure ). ,, Although the biological control strategy for nematodes has received more attention, chemical nematicides are still the main means at present. New chemical nematicides are required to meet the huge market demands and control the growing resistance …”

“…In our previous work, we found a series of novel nematicidal compounds containing a fused ring; the lethal concentration 50% (LC 50 ) value of the most active compound against M. incognita after exposed for 72 h (LC 50/72 h ) was 3.20 mg/L . In this article, based on the structure of compound A , an aurone analogue with a high similarity score was discovered by the SHAFTS (Figure ).…”

“…(Z)-2-(Thiazol-2-ylmethylene)benzofuran-3(2H)-one(8).25 mp 139−141 °C). (Z)-2-(Pyridin-3-ylmethylene)benzofuran-3(2H)-one(10). White solid, yield: 71%.…”

“…The nematicidal activity of compounds against M. incognita and the influence of compound 32 on C. elegans were evaluated according to the previously reported methods 10. M. incognita were cultured by the Huzhou Modern Agricultural Biotechnology Innovation Center, Chinese Academy of Sciences, China.…”