2013
DOI: 10.4028/www.scientific.net/amr.641-642.7
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Synthesis of 1,1-Bis(hydroxymethyl)cyclopropane as Intermediate for Montelukast Sodium

Abstract: 1,1-Bis(hydroxymethyl)cyclopropane was synthesized by reaction dibromoneopentyl glycol with zinc powder at mole ratio of nDG:nzinc=1:1.05 and 80oC (slightly reflux) for 7 hours. Under optimal conditions, yield and purity of the title compound were 87.3% and 98.67%, respectively. Dibromoneopentyl glycol was also prepared in 91.7% yield with pentaerythritol and hydrobromic acid as material and diethyl sulfate as catalyst under reflux for 10 hours. Structural characterization of 1,1-bis(hydroxymethyl)cyclopropane… Show more

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