Synthesis of 1,1-disubstituted-2,6-diarylcyclohexane-4-ones catalyzed by KF/basic Al2O3 under ultrasound

Abstract

1,1-Disubstituted-2,6-diarylcyclohexane-4-ones have been synthesized via double Michael addition of 1,5-diaryl-1,4-pentadien-3-one with various active methylene compounds such as dimethyl malonate, diethyl malonate, methyl cyanoacetate and ethyl cyanoacetate catalyzed by KF/basic alumina under ultrasound irradiation to give good yields within a short time.

A Facile Method for the Synthesis of 2-(3-aryl-2-cyanopropenoyl)-1-methylpyrrole catalysed by KF/Al2O3 with microwave irradiation

“…Due to its strongly basic nature it has been used as a replacement for organic bases in a number of organic reactions. [13][14][15][16] In this report, we describe a simple and economical reaction of aromatic aldeheydes 1 with 2-cyanoacetylpyrrole 17 2 catalysed by KF (40% by weight)/Al 2 O 3 in dry ethanol under microwave irradiation. (Scheme 1 and Table 1).…”