Synthesis of [1,2,3]Selenadiazolo[4,5‐e]benzofuran of Benzothiophene, [1,2,3]Thiadiazolo[4,5‐e]benzofuran or Benzothiophene, and 2‐Benzofuranyl‐1,3,4‐oxodiazole Derivatives.

Abstract

Synthesis of [1,2,3]Selenadiazolo[4,5-e]benzofuran of Benzothiophene, [1,2,3]Thiadiazolo[4,5-e]benzofuran or Benzothiophene, and 2-Benzofuranyl-1,3,4-oxodiazoleDerivatives. -With regard to the potential biochemical and physiological activity of the title compounds, these structures are prepared as drugs against tropical diseases. Some unexpected compounds are obtained prepared according to literature methods. Thus, attempted cyclization of (V) with both bromine and lead tetraacetate fails. Also, reaction of (XIIa) with thionyl chloride does not give the 4,5-dihydrobenzofuran derivative but the oxidized benzofuran derivative (XIV). -(SHEKARCHI, M.; ELLAHIYAN, F.; AKBARZADEH, T.; SHAFIEE*, A.; J. Heterocycl. Chem. 40 (2003) 3, 427-433; Dep. Chem., Fac. Pharm., Tehran Univ., Tehran, Iran; Eng.) -H. Hoennerscheid 43-091