Synthesis of 1,2,3-triazole-thymol derivatives as potential antimicrobial agents

Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics

“…Thus, replacing hydrogen with halogen improved the antibacterial activity of the compounds. Moreover, compound 19 (Figure 21) with a mean zone inhibition of 24.7 mm was the most active antibacterial compound among its counterparts, and it was also comparable to the control drug with a 30 mm mean zone of inhibition [68].…”

“…Although the hybrids were selective towards the antibacterial strains, the introduction of the thymol moiety was responsible for the improved activity [66,67]. 1,2,3-triazole-thymol hybrid derivatives were synthesized by Addo et al after they displayed promising antibacterial results when evaluated against several bacterial strains [68]. Most of the synthesized compounds displayed a similar or superior antibacterial activity comparable to that of ampicillin, the control, depending on the bacterial strains used.…”

“…Thus, replacing hydrogen with halogen improved the antibacterial activity of the compounds. Moreover, compound 19 (Figure 21) with a mean zone inhibition of 24.7 mm was the most active antibacterial compound among its counterparts, and it was also comparable to the control drug with a 30 mm mean zone of inhibition [68]. Bhoi et al synthesized nine benzimidazole-carvacrol hybrids and evaluated them against four different bacterial strains, such as E. coli, S. aureus, S. pyogenus, and P. aeruginosa [69].…”

“…The trend was inconsistent and depended on the type of bacterial strain used. Hybridizing natural products with azoles and the structural modification of the hybrids can result in effective antibacterial agents that can overcome resistant bacterial strains [68][69][70][71]. Summary of antibacterial activity, SAR, and mechanism of action of carvacrol and thymol hybrids is shown in Table 3.…”

Synthesis and biological evaluation of novel 1,2,3-triazole hybrids of cabotegravir: identification of potent antitumor activity against lung cancer

“…The incorporation of 1,2,3-triazole units into drug molecules using click chemistry approaches has gained significant popularity due to their ability to form stable compounds with hydrogen bonding interactions, enhancing drug solubility and efficacy ( Kolb and Sharpless, 2003 ). Consequently, drugs containing 1,2,3-trazole structures have been developed and reported to possess diverse biological properties, including anticancer ( Yang et al, 2020 ; Hasanpour et al, 2021 ), antimicrobial ( Lal et al, 2018 ; Addo et al, 2022 ), antiviral ( Kutkat et al, 2022 ), and anti-HIV activities ( Feng et al, 2021 ). Figure 1 illustrates examples of drugs containing 1,2,3-triazole structures with different biological activities.…”