Synthesis of 1, 2, 3-triazolo-piperazines compounds and their screening for Anticancer activity using C6 Glioma cell lines

Abstract

A series of 1,2,3-triazolo-piperazines compounds were synthesized and characterized by 1 HNMR, 13 C NMR, IR, Mass spectroscopy and screened for anticancer activity using C6 Glioma cell lines. Among 15 compounds of triazole series, four of the compounds showed the most potent antiproliferative activity as well as good selectivity between cancer and normal cells. These compounds 1 (IX), 2 (VIII1), 3 (IX2) and 4 (VII2) exhibited good anti-proliferation activity with IC50 values of 0.05µM against C6 glioma cell lines evaluated in vitro.