Synthesis of 1,2:5,6‐Di‐O‐isopropylidene‐3‐O‐[3‐(5‐fluorouracil‐1‐yl)‐propionoyi]‐α‐D‐glucofuranose and its antitumor activity

Abstract

In order to provide a less toxic 5‐fluorouracil derivative, 1,2:5,6‐di‐O‐isopropylidene‐3‐O‐[3‐(5‐fluorouracill‐yl)‐propionoyl]‐α‐D‐glucofuranose, which was the derivative of 5‐fluorouracil combining indirectly to 3‐position of diacetoneglucose, was synthesized, and its antitumor activity was tested.

Modified D-Glucofuranose Computationally Screening for Inhibitor of Breast Cancer and Triple Breast Cancer: Chemical Descriptor, Molecular Docking, Molecular Dynamics and Qsar

“…But with the help of the newly developed computational chemistry method, it has been possible to design an effective drug, and check all the pharmacokinetic parameters of the drug in a concise time, such as pass prediction, docking, molecular dynamics, and ADMET easily (24). On the other hand, the D-glucofuranose and its derivative have already been identified as a potential compound by many renowned researchers (25) for the treatment as an antifungal (25) antibacterial, antiviral (26)(27)(28)(29), and anticancer activity (30). Since D-glucofuranose and its derivatives have already been found to have potential as antimicrobial and anticancer before (27,29,31,32), this is why derivatives of this compound have been taken and performed different types of computational studies.…”

Synthesis of disubstituted- and deoxydisubstituted- derivatives of α-D-xylofuranose as anticancer agents

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Among them, several branched-chain sugar derivatives, [11][12][13][14][15] as well as some low molecular weight sugar derivatives with aminoalkyl appendages, [1][2][3][4] have shown potent anticancer activity. In continuation of our efforts to find potent anticancer agents and on the basis of the correlation of anticancer activity in vitro, in vivo, and lipophilicity of the compounds of our previous work on aminoalkyl derivatives of sugars, 4,16 we have synthesized disubstituted-and deoxydisubstituted-derivatives of α-D-xylofuranose and evaluated them for anticancer activity.…”