Synthesis of 1‐[3‐(4‐Benzotriazol‐1/2‐yl‐3‐fluorophenyl) ‐2‐oxo‐oxazolidin‐5‐ylmethyl]‐3‐substituted‐thiourea Derivatives as Antituberculosis Agents.

Abstract

Among this novel series of compounds the mixture of (VIIIb) and (IXb) is the most interesting one, showing an excellent antimycobacterial activity in vitro. -(DIXIT, P. P.; PATIL, V. J.; NAIR, P. S.; JAIN, S.; SINHA, N.; ARORA*, S. K.; Eur. J. Med. Chem. 41 (2006) 3, 423-428; Med. Chem. Div., New Chem. Entity Res., Pune 411 042, India; Eng.) -K. Schneider 34-127

Antituberculosis Drug Research: A Critical Overview

“…Dixit et al synthesized substituted thiourea derivatives of oxazolidinones ( 322a‐322j ) and screened them against M. tb ATCC27294 strain using isoniazid (MIC = 0.25 μg/mL) and linezolid (MIC = 0.5 μg/mL) as reference drugs . Compounds with amino ( 322e ), 2‐pyridyl ( 322g ), 1‐pyrrolidinyl ( 322h ), and 1‐piperidinyl ( 322i ) groups exhibited potent activity with MIC value in the range 0.5–1.0 μg/mL.…”

Synthesis and anticonvulsant activity of substituted thiourea derivatives

“…Melting points were determined with a "Schmelzpunktbestimmer" SMP II and were uncorrected. 1 H-NMR spectra were recorded in DMSO on a Bruker Avance-DPX-400 spectrometer in DMSO-d 6 and chemical shifts were given in δ ppm with tetramethylsilane. The splitting patterns of 1 H-NMR were designed as follows: s: singlet, d: doublet, t: triplet, q: quarlet, m: multiplet.…”

“…Some thiourea derivatives possess valuable biological pharmacological activities such as, anti-HIV / antiviral (1-4), antitubercular (5)(6)(7)(8), analgesic (9-10) and anticancer properties (11)(12)(13). In addition, urea and thioureas (14)(15)(16) have emerged as structurally novel anticonvulsant.…”