Synthesis of 1, 3, 4-Oxadiazole

Farooqui, Maqdoom; Nazimuddin, Syed

doi:10.5958/0974-4150.2017.00026.8

Asia. Jour. Rese. Chem.

2017

DOI: 10.5958/0974-4150.2017.00026.8

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Synthesis of 1, 3, 4-Oxadiazole

Maqdoom Farooqui¹,

Syed Nazimuddin²

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Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique

Saaid

Dawood

Marbeen

2018

MJS

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In the present study, a new of 1,3,4-oxadizole derivatives(4a1,4a2,4b1,4b2) were synthesized using an ultrasonic technique. Benzohydrazine and its substituted (2a, 2b) were obtained from the reaction of hydrazin with benzoylchloride and its substituted (1a, 1b). Compounds (2a, 2b) react with chloroacetic acid to form compounds (3a,3b) which react with p-phenylene diamine and hydrazine in presence of DMSO as a solvent to obtain new compounds (4a1,4a2, 4b1,4b2) by ultrasonic technique. The structures of the synthesized compounds were elucidated by spectral data: infrared spectra (FT-IR) and 1HNMR and CHN analysis. The synthesis compounds (4b1, 4b2, 4a1, and 4a2) were evaluated for antibacterial (Staphylococcus1 aureus) by the serial dilution method

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Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique

Saaid

Dawood

Marbeen

2018

MJS

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Synthesis of 1,3-Benzoxazepine-1,5-diones containing Oxadiazole unit with Assessment of their verves Athwart Bacteria

Abood

Suhail

Chafcheer

2021

RJPT

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Treatment of 4-aminobenzoyl hydrazide (1) with (CS2) and potassium hydroxide in absolute (EtOH) resulted in formation of 5-(4-aminophenyl)-2-thiol-1,3,4-oxadiazole (2). Compound (2) has been converted to the diazonium salt which reacted with 2-hydroxybenzaldehyde for producing the aldehyde derivative (3). Reaction of compound (3) with (4-nitroaniline, 3-nitroaniline, 2-nitroaniline, 4-chloroaniline, 2-chloroaniline, 2,4-dichloroaniline and 4-bromoaniline) by (MW) method in (EtOH) afforded seven Schiff bases (4a–g). Cycloaddition of imines (4a–g) with phthalic anhydride in microwave oven gave seven 1,3-benzoxazepine-1,5-diones (5a–g) bearing oxadiazole moiety. Screening verves of final benzoxazepines was done on Staphylococcus aurous and Escherichia coli. The implications explained that compounds (5b, 5c, 5d, 5e, 5f and 5g) possess higher effect than gentamycin against Staphylococcus aurous. Moreover, the 1,3-oxazepine-1,5-diones (compounds 5a, 5b, 5c, 5d, and 5g) appeared better action against Escherichia coli comparably with the standard antibiotic.

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Synthesis of 1, 3, 4-Oxadiazole

Cited by 2 publications

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Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique

Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique

Synthesis of 1,3-Benzoxazepine-1,5-diones containing Oxadiazole unit with Assessment of their verves Athwart Bacteria

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