Synthesis of 1,3,4-Oxadiazoles with 4-Methoxynaphthalene Ring: Discovering New Compounds with Antimicrobial Activity

Abstract

Background: Paracoccidioidomycosis (PCM) is a systemic infection caused by Paracoccidioides spp. ( Pb). PCM can be associated or clinically confused with tuberculosis (TB), another pulmonary infection, caused by Mycobacterium tuberculosis ( Mtb). Futhermore, the long treatment time of TB and PCM and the cases of TB drug resistance impose difficulties for the cure of these diseases. Results: New 1,3,4-oxadiazoles containing the 4-methoxynaphthalene ring were synthesized and their antimicrobial activity was evaluated against Pb and Mtb. The derivative 6n (with 2-hydroxy-5-nitrophenyl subunit) is the most promising of the series. Conclusion: The 1,3,4-oxadiazole 6n can be used as a prototype drug candidate, with anti- Pb and anti- MTb activities, showing a broad-spectrum profile for the treatment of both pulmonary infections.