Synthesis of 1,3-Difunctionalized Amine Derivatives through Selective C−H Bond Oxidation

Complementary Strategies for Directed C(sp3)−H Functionalization: A Comparison of Transition‐Metal‐Catalyzed Activation, Hydrogen Atom Transfer, and Carbene/Nitrene Transfer

“…[205] In both dirhodium(II)-catalyzed CÀHi nsertion and amination, the stereochemical outcome can be explained by the aforementioned concerted, but asynchronous,mechanism.…”

Alcohols or Masked Alcohols as Directing Groups for C–H Bond Functionalization

“…26 They first demonstrated that sulfamates can undergo a Rh-catalyzed nitrenoid insertion to give six-membered ring products, which can be viewed as a 1,3-amino alcohol equivalent (Scheme 18). 27 The site-selectivity for the γ-CH bond was excellent, and the authors rationalized that the strong bias for the six-membered ring formation vs. five-membered formation was due to the elongated SO and SN bonds and the obtuse NSO angle, which are quite similar with the metrical parameters of the heterocycle. Nevertheless, it is also possible to afford the five-membered ring products when obviating the sixmembered ring formation pathway.…”

Silver-catalysed direct amination of unactivated C–H bonds of functionalized molecules

“…1a) [16][17][18][19][20] . Many chemists have devoted themselves to searching for practical and convenient synthetic methods for accessing such ubiquitous structural units by direct oxidative amination of C-H bonds [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] . In fact, efforts toward such a goal can be traced back to the historical Hofmann-Löffler-Freytag reaction in early 19th century and its advanced versions-the Baldwin and Doll modification and the Suárez modification [21][22][23][24][25][26][27][28][29] .…”