Synthesis of 1,3-Oxazepine Derivatives Derived from 2-(1H-Benzo[d][1,2,3]Triazol-1-yl) Acetohydrazide by Using Microwave Irradiation

Taha, Nihad I.

doi:10.4236/ijoc.2017.73016

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…The extensive research and documentation have been done on the oxazepine synthesis over time. It is made by combining maleic, phthalic, and succinic anhydrides with Schiff base or hydrazone [8].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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In this research, the first Schiff bases (1) were prepared from the reaction of 4-dimethyl amino benzaldehyde with hydrazine derivative in the presence of glacial acetic acid, and then, from reaction of Schiff bases (1) with sodium azide, mercaptoacetic acid, chloroacetyl chloride, and various anhydrides (maleic anhydride, succinic anhydride, and 3-nitro phathalic anhydride), tetrazole (2), thiazolidinone (3), β-lactam (4), and oxazepine compounds (5-7), respectively were synthesized and their physical characteristics were studied. 1 H-NMR and infrared spectra were used to identify the produced derivatives. Likewise, the antibacterial strains and fungi revealed the activity against Gram-positive bacteria (Stapylococcus), Gram-negative bacteria (Escherichia coli), and Gram-positive bacteria (Candida albicans).

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Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Due to the importance of this class of organic compounds, many researchers were able to prepare many oxazepine derivatives from Schiff bases to obtain more than one heterogeneous ring of varying size (18)(19)(20)(21). Therefore, our research aims to prepare compounds containing the pyrazole ring with the oxazepine ring and to investigate their anti-cancer activity and how much in Scheme-1: which shows the progress and steps of the reactions: Scheme 1.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

Azzawi

Hussein

2022

ijhs

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The research included the preparation of two Schiff bases MA1,2 starting from1-methyl-pyrazole-4-carbaldehyde with 4-chloroaniline or 4-amino antipyrine in equal moles in the presence of glacial acetic acid. Then xazepane rings MA (3-6) were prepared from MA1,2 with phthalic anhydride or maleic anhydride. The prepared chemical formulas were confirmed using FTIR, 1HNMR, and 13CNMR spectroscopy. The toxicity activity of the compound MA2 against breast cancer MDA and REF cells was tested at seven concentrations (400, 200, 100, 50, 25, 12.5, 6.25) ml/ µg. The study also showed the lowest inhibition rate for MDA cancer line cells at 6.25 µg/ml by (4%) and the highest inhibition rate at 400 µg/ml by 77%, and the study showed the compound with the highest toxicity in healthy cells (64%-80%).

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“…Oxazepines are heterocyclic unsaturated compounds, incorporating two hetero atoms (oxygen and nitrogen). There are many synthetic strategies for synthesis of oxazepines, using gold-, palladium-and rhodium-based catalysts, [1][2][3] under microwave irradiation, 4 and under catalyst-free conditions 5 as well; all these strategies leading to the formation of 1,3-oxazepines-4,7-diones. Oxazepines were synthesized to be evaluated for their potential activities, e.g.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Tetrachloro-1,3-Oxazepine Derivatives and Evaluation of their Biological Activities

Kshash

2020

ACSi

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6,7,8,9-Tetrachloro[1,3]oxazepine-1,5-dione derivatives 1b-10b have been synthesized by reacting Schiff bases 1a-10a with tetrachlorophthalic anhydride (TCPA) under (2 + 5 → 7) cycloaddition reaction conditons. All reactions had been monitored using TLC. FT IR and melting points have been used to characterize the Schiff bases; oxazepine compounds 1b-10b were characterized using FT IR, 1 H NMR and their melting points. Biological activity for oxazepine compounds has been evaluated against bacterial types (Staphylococcus aureus, Escherichia coli, Klebsiella spp.) and against a fungus (Geotrichum spp.). Variable activities have been observed against used strains of bacteria and fungi.

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Synthesis of 1,3-Oxazepine Derivatives Derived from 2-(1H-Benzo[d][1,2,3]Triazol-1-yl) Acetohydrazide by Using Microwave Irradiation

Cited by 7 publications

References 19 publications

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Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

Synthesis and Characterization of Tetrachloro-1,3-Oxazepine Derivatives and Evaluation of their Biological Activities

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