Synthesis of 1‐amidoalkyl‐2‐naphthol derivatives using a magnetic nano‐Fe₃O₄@SiO₂@Hexamethylenetetramine‐supported ionic liquid as a catalyst under solvent‐free conditions

Abstract

Hexamethylenetetramine-functionalized silica-coated nano-Fe 3 O 4 particles (MNPs@Hexamethylenetetramine) were prepared as a reusable heterogeneous catalyst using a facile process. The catalyst was synthesized and characterized using infrared, X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, and vibrating sample magnetometer. This magnetic nanocatalyst was employed as an efficient, reusable, and environmentally benign heterogeneous catalyst for the synthesis of amidoalkylnaphthol derivatives from a one-pot three-component condensation reaction of beta-naphthol, aldehydes, and amides in good to excellent yields, Moreover, this catalyst can be easily recovered by using a magnetic field and directly reused for at least seven runs without sign ificant loss of its activity. K E Y W O R D S1-amodoalkyl-2-naphthol, magnetic nanoparticles, multicomponent reactions, solvent free, ultrasound irradiation

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

“…The recent literature precedents are summarized in Table 3, Refs. [73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92].…”

“…In all instances the amidoalkyl naphthols were isolated in good to excellent yields in short reaction times. Notably, this class of catalysts exhibited a very good level of recyclability [21,[79][80][81][82][83][84]. Furthermore, the biological activity of some of the obtained products was examined against Staphylococcus aureus and Escherichia coli.…”

Heterogeneous SO3H@Fe3O4 magnetic nanocatalyst as an efficient and reusable medium for the synthesis of 3,3′‐(arylmethylene)‐bis‐(4‐hydroxycoumarin), bis‐(indolyl)‐methane, and 1,8‐dioxo‐octahydroxanthene derivatives

“…[1][2][3] Nanoparticles have many considerable applications because of their potent physical and chemical features, including support for bonding with homogenous catalysts, drug delivery, and extraction of heavy and harmful ions from wastewater. [4][5][6][7][8] They have important outcomes regarding site-specific drug targeting due to their biological and pharmaceutical characteristics for treating different diseases such as HIV infection, cancer, and disorders of the nervous system. [9] A great number of supported nanocatalysts can be isolated by centrifugation or filtration, which result in the loss of catalysts in a large number of organic transformations.…”