Synthesis of 1-Methylbenzimidazoles
from Carbonitriles

Sluiter, Jonas; Christoffers, Jens

doi:10.1055/s-0028-1087383

Cited by 6 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another approach for the synthesis of 2-substituted BnZ was published by Cui et al in 2012 for producing 1,2-phenylenediamines and triacyloxyborane intermediates, which were produced via the interaction between carboxylic acids [E] and borane-THF, to yield 2-substituted BnZ [ 13 ]. N-methyl-1,2-phenylenediamine, sodium hydride, and carbonitriles [F] were used as the starting ingredients by Sluiter and Christoffers in 2009 [ 14 ]. Wray synthesized [ 1 ] 1H-indazoles from common arylamino oximes in 2010 in the presence of several bases, but the synthesis of BnZ was only improved by one base, i.e., triethylamine [G] [ 15 ].…”

Section: Synthesis Of Benzimidazolementioning

confidence: 99%

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

Patel¹,

Avashthi²,

Gacem

et al. 2023

Molecules

View full text Add to dashboard Cite

Heterocyclic compounds are significant lead drug candidates based on their various structure–activity relationships (SAR), and their use in pharmaceutics is constantly developing. Benzimidazole (BnZ) is synthesized by a condensation reaction between benzene and imidazole. The BnZ structure consists of two nitrogen atoms embedded in a five-membered imide ring which is fused with a benzene ring. This review examines the conventional and green synthesis of metallic and non-metallic BnZ and their derivatives, which have several potential SARs, along with a wide range of pharmacological properties, including anti-cancer, anti-inflammatory, anti-microbial, anti-tubercular, and anti-protozoal properties. These compounds have been proven by pharmacological investigations to be efficient against different strains of microbes. Therefore, in this review, the structural variations of BnZ are listed along with various applications, predominantly related to their biological activities.

show abstract

Section: Synthesis Of Benzimidazolementioning

confidence: 99%

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

Patel¹,

Avashthi²,

Gacem

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

An Efficient Synthesis of 2-Substituted Benzimidazoles via Photocatalytic Condensation of o-Phenylenediamines and Aldehydes

et al. 2016

View full text Add to dashboard Cite

A photocatalytic method has been developed for the efficient synthesis of functionalized benzimidazoles. This protocol involves photocatalytic condensation of o-phenylenediamines with various aldehydes using the Rose Bengal as photocatalyst. The method was found to be general and was successfully employed for accessing pharmaceutically important benzimidazoles by the condensation of aromatic, heteroaromatic and aliphatic aldehydes with o-phenylenediamines, in good-to-excellent yields. Notably, the method was found to be effective for the condensation of less reactive heterocyclic aldehydes with o-phenylenediamines.

show abstract