Synthesis of (1′RS,3′SR)- and (1′RS,3′RS)-5-ethyl-5-(3′-hydroxy-1′-methylbutyl)barbituric acid

Carroll, F. Ivy; Blackwell, J. T.

doi:10.1039/c29700001616

Cited by 4 publications

(3 citation statements)

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“…It caused damage to DNA and disruption of mitochondrial membrane potential, released cytochrome c, and led to mitochondrial-dependent apoptosis [3,28,29]. Although AgNPs Unauthenticated Download Date | 6/7/19 11:06 AM administration caused a statistically significant increase in apoptosis, all obtained results of tumors from the AgNPs group are in agreement with the results for apoptosis in spontaneous GBM, which was at the level of <3.00% [30][31][32][33]. It is well known that malignant tumor cells, such as GBM, are extremely resistant to apoptosis and particularly resistant to radiation and chemotherapy.…”

Section: Discussionsupporting

confidence: 81%

The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

Urbańska¹,

Pająk²,

Orzechowski³

et al. 2016

Nano Online

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Recently, it has been shown that silver nanoparticles (AgNPs) provide a unique approach to the treatment of tumors, especially those of neuroepithelial origin. Thus, the aim of this study was to evaluate the impact of AgNPs on proliferation and activation of the intrinsic apoptotic pathway of glioblastoma multiforme (GBM) cells cultured in an in ovo model. Human GBM cells, line U-87, were placed on chicken embryo chorioallantoic membrane. After 8 days, the tumors were divided into three groups: control (non-treated), treated with colloidal AgNPs (40 μg/ml), and placebo (tumors supplemented with vehicle only). At the end of the experiment, all tumors were isolated.Assessment of cell proliferation and cell apoptosis was estimated by histological, immunohistochemical, and Western blot analyses. The results show that AgNPs can influence GBM growth. AgNPs inhibit proliferation of GBM cells and seem to have proapoptotic properties. Although there were statistically significant differences between control and AgNP groups in the AI and the levels of active caspase 9 and active caspase 3, the level of these proteins in GBM cells treated with AgNPs seems to be on the border between the spontaneous apoptosis and the induced. Our results indicate that the antiproliferative properties of silver nanoparticles overwhelm proapoptotic ones. Further research focused on the cytotoxic effect of AgNPs on tumor and normal cells should be conducted.

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Section: Discussionsupporting

confidence: 81%

The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

Urbańska¹,

Pająk²,

Orzechowski³

et al. 2016

Nano Online

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“…This is in contrast with the type celadonite of Wise and Eugster (1964), or the example given by Buckley et al (1978). Such amalgamation of these two reflections is more typical of glauconite (see, for example, Carroll, 1970), but could also be due to the presence of a more aluminous and/or K-deficient phase such as a 1M muscovite with the 130 reflection near to 2.58 A (Yoder and Eugster, 1955), or possibly a phengite. The lack of published powder diffraction data for phengites makes this latter point speculative, but receives support from the review of the mica group by Bailey (1980).…”

Section: Resultsmentioning

confidence: 82%

Celadonite-aluminous-glauconite: an example from the Lake District, UK

Loveland

Bendelow

1984

Mineral. mag.

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ABSTRACT. An occurrence of a celadonite-like mineral in a weathered basalt in the Lake District has been investigated by X-ray diffraction, X-ray fluorescence, electron microprobe, and infra-red spectroscopic methods. The bulk composition of the mineral corresponds to an aluminous-glauconite. The data show that the mineral is most probably a celadonite-muscovite or celadonite-illite mixture, although a celadonite-phengite cannot be entirely discounted. Approximately 10~o smectite layers are also present. The results suggest that re-examination of many aluminous glauconites may show them to be mixtures of this type.

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“…Substituting this expression for X in (9), we have (10) where in the second line of (10) analytes present in both samples. This does not give us any information yet on which analytes are present in both samples.…”

Section: The Sk (Sanchez and Kowalski) Methodsmentioning

confidence: 95%

Some theoretical results on second‐order calibration methods for data with and without rank overlap

Kiers¹,

Smilde

1995

Journal of Chemometrics

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SUMMARYGRAM. a method for second-order calibration, has been introduced by Sanchez and Kowalski and later modified by Wilson, Sanchez and Kowalski. The methods are based on the claim that, in cases without measurement error they yield correct estimates for the concentration ratios and profiles of (rank-one) analytes present in sample and mixture. This claim has not been proven rigorously. In the present paper, rigorous proofs are given for situations where the claims are valid indeed. In addition, it is shown that PARAFAC, an alternative method for second-order calibration, can be used to obtain the same results.Next it is shown that the claims do not hold in cases with 'rank overlap' (partly overlapping profiles) and it is proven that a procedure by Wang et al. can still be used to assess some of the concentration ratios. A general framework is provided for a variety of second-order calibration problems and the extent to which quantitative and qualitative information can be expected is given.KEY WORDS GRAM; PARAFAC; rank overlap; second-order calibration INTRODUCTlONIn analytical chemistry it is often desired to determine the presence of certain analytes in a mixture. If an analyte is present, it is desirable to determine the concentration of it. For this purpose one can use so-called second-order instruments. Examples of such second-order instruments are LC-W, GC-MS and MS-MS, among others. These instruments are called second-order instruments because they generate a response matrix for a single sample. Specifically, for a pure analyte sample (a sample in which only one analyte generates the response) such instruments may, ignoring measurement error, produce a calibration matrix of rank one, which can be written as N =xyT (1)

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Synthesis of (1′RS,3′SR)- and (1′RS,3′RS)-5-ethyl-5-(3′-hydroxy-1′-methylbutyl)barbituric acid

Cited by 4 publications

References 0 publications

The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

Celadonite-aluminous-glauconite: an example from the Lake District, UK

Some theoretical results on second‐order calibration methods for data with and without rank overlap

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