Synthesis of 1‐<sup>13</sup>C and 3‐<sup>13</sup>C isotopic isomers of aspartic and glutamic acids

Fotadar, Upinder; Cowburn, David

doi:10.1002/jlcr.2580200811

Labelled Comp Radiopharmac

1983

DOI: 10.1002/jlcr.2580200811

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Synthesis of 1‐¹³C and 3‐¹³C isotopic isomers of aspartic and glutamic acids

Upinder Fotadar

David Cowburn

Abstract: Convenient r o u t e s t o 1-C and 3-C l a b e l e d g l u t a m i c and a s p a r t i c a c i d s and t o t h e i r p r e c u r s o r s are d e s c r i b e d .

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2024

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¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

Rodygin,

Bogachenkov,

Gyrdymova

et al. 2024

Chemistry Methods

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The incorporation of a labeled 13C atom provides a plethora of opportunities in organic synthesis and catalysis. Structure of complicated compounds can be successfully confirmed using the precise location of a labeled carbon atom; a reaction mechanism can be supported by the presence or absence of a label in reaction products; metabolic pathways of biological compounds can be found out depending on labeled products; the concentration of analyzed labeled compounds can be significantly lower for recording and successful interpretation of NMR spectra, etc. This review aims to provide a researcher with common and promising strategies for the synthesis of labeled compounds so that a researcher can select an appropriate route to save valuable labeled material. All the labeling approaches were considered based on starting labeling source. Ideological aim of the review is to demonstrate the opportunities for label incorporation so that a researcher can find the improvements in his own topic using labeled compounds. Utilization of labeled compounds in catalysis and studying reaction mechanisms were also considered to demonstrate the capabilities of labeled compounds, which may be useful in specific tasks and applications. The potential of labeled compounds in bioactive compound metabolite analysis was demonstrated on selected examples.

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¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

Rodygin,

Bogachenkov,

Gyrdymova

et al. 2024

Chemistry Methods

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Chemo‐enzymatic synthesis of specifically stable‐isotope labelledL‐glutamic acid and 2‐oxoglutaric acid

Cappon¹,

Baart²,

Walk³

et al. 1991

Recl. Trav. Chim. Pays‐Bas

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Synthesis of 1‐¹³C and 3‐¹³C isotopic isomers of aspartic and glutamic acids

Abstract: Convenient r o u t e s t o 1-C and 3-C l a b e l e d g l u t a m i c and a s p a r t i c a c i d s and t o t h e i r p r e c u r s o r s are d e s c r i b e d .

Cited by 2 publications

References 13 publications

¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

Chemo‐enzymatic synthesis of specifically stable‐isotope labelledL‐glutamic acid and 2‐oxoglutaric acid

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Synthesis of 1‐13C and 3‐13C isotopic isomers of aspartic and glutamic acids

Abstract: Convenient r o u t e s t o 1-C and 3-C l a b e l e d g l u t a m i c and a s p a r t i c a c i d s and t o t h e i r p r e c u r s o r s are d e s c r i b e d .

Cited by 2 publications

References 13 publications

13C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

13C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

Chemo‐enzymatic synthesis of specifically stable‐isotope labelledL‐glutamic acid and 2‐oxoglutaric acid

Contact Info

Product

Resources

About

Synthesis of 1‐¹³C and 3‐¹³C isotopic isomers of aspartic and glutamic acids

¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications