Synthesis of 15β‐Hydroxyalkyl‐Substituted (17Z)‐Pregn‐17‐enes, Their Ethers and Esters.

Abstract

Steroids U 0300Synthesis of 15β-Hydroxyalkyl-Substituted (17Z)-Pregn-17-enes, Their Ethers and Esters. -A series of 15β-alkenyl substituted pregnenes (III) is prepared using copper-catalyzed Grignard reagent addition to ketosteroid (I). Further modifications of the products are described in order to obtain pharmaceutically interesting agents. -(BARANOVSKII, A. V.; LITVINOVSKAYA, R. P.; KHRIPACH, V. A.; Russ.