Synthesis Of 2′(2′,6′)-(Di)Halogenoisoxazolopodophyllic Acids-Based Amides Derived from a Naturally Occurring Lignan Podophyllotoxin and Their Acaricidal Activity

Due to the extensive use of agrochemicals resulting in the emergence of pesticide resistance and ecological environment problems, the research and development of new alternatives for crop protection is highly desirable. In order to discover potent natural product-based insecticide candidates, a series of new cholesterol ester derivatives containing cinnamic acid-like fragments at the C-7 position were synthesized. Some derivatives showed potent pesticidal activities. Against Mythimna separata Walker, compounds 2a, Id, Ig, and IIg showed 2.1–2.4-fold growth-inhibitory activity of the precursor cholesterol. Against Plutella xylostella Linnaeus, compounds Ig, IIf, and IIi exhibited 1.9–2.1-fold insecticidal activity of cholesterol. These results will pave the way for the future synthesis of cholesterol-based derivatives as agrochemicals.

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Semisynthesis of Conjugates from Matrine/Cholesterol with Piperic Acid/ Piperic Acids-Like as Insecticidal and Aphicidal Agents

Lv,

Jiang,

Hao

et al. 2022

HETEROCYCLES

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Synthesis Of 2′(2′,6′)-(Di)Halogenoisoxazolopodophyllic Acids-Based Amides Derived from a Naturally Occurring Lignan Podophyllotoxin and Their Acaricidal Activity

Cited by 4 publications

References 26 publications

Review of lignans from 2019 to 2021: Newly reported compounds, diverse activities, structure-activity relationships and clinical applications

Review of lignans from 2019 to 2021: Newly reported compounds, diverse activities, structure-activity relationships and clinical applications

Semisynthesis and Pesticidal Activities of Novel Cholesterol Ester Derivatives Containing Cinnamic Acid-like Fragments

Semisynthesis of Conjugates from Matrine/Cholesterol with Piperic Acid/ Piperic Acids-Like as Insecticidal and Aphicidal Agents

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