Synthesis of 2,4-diphenyl-2,3-dihydro-1h-1,5-benzodiazepine

Preparation of some light-sensitive 2-nitrophenyl-2,3-dihydro-1H-benzodiazepines

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] An alternative synthesis employs an acetophenone derivative and a 1,2-diamine (2:1 equivalents ratio) in acidic medium. 3,4,6 Benzodiazepines are important compounds because of various biological activities.…”

Sulfur–doped Graphene as an Efficient Metal–free Carbocatalyst for the Synthesis of 1,5–Benzodiazepines Derivatives

“…On the other hand, Yaremenko et al . found that if an acidic catalyst was used in place of the base, exclusively benzimidazole would be obtained . In spite of experimental evidence for the formation of corresponding benzimidazoles from benzodiazepine derivatives, a detailed mechanistic investigation is not available for this rearrangement.…”

Chalcone derived benzoheterodiazepines for medicinal applications: A Two‐pot and one‐pot synthetic approach

“…Benzoheterodiazepine derivatives are designed from different reactants such as cinnamoylacetonitrile [64], hydrazone [65], flavone [66], chalcone [67], α-haloketones [68,69], ethyl acetoacetate [70], cinnamoyl cyanide [71], propargylic alcohols [72], or ketones [73][74][75]. The condensation of diamines (i.e., o-phenylenediamine, o-aminothiophenol, o-aminophenol) and chalcones [76,77] is common under different modes of reactions (i.e., stirring [78], grindstone [79], reflux [80,81], MW [82,83], and ultrasonic irradiations [84,85]) in the presence of catalysts (i.e., piperidine [86,87], NaOH [88,89], NaOAc [90], acetic acid [91,92], trifluoroacetic acid [93], InCl 3 [94], alumina [82], volcanic ash [95], Ti(OiPr) 4 [77], MgO-ZrO 2 [96], SmI 2 [78], SiO 2 [97], Al 2 O 3 [80], TiCl 4 /Sm [98], Bi(NO 3 ) 3 -Al 2 O 3 [99], La Y zeolite [100], HClO 4 -SiO 2 [101], Fe 3 O 4 [102], B(HSO 4 ) 3 …”