Synthesis of 2-amino-4-(methoxycarbonyl)Phenylboronic Acid Hydrochloride, a key Intermediate for the Synthesis of Quinolines Derivatives

Abstract

A practical and efficient process for the synthesis in good yield of 2-amino-4-(methoxycarbonyl)phenylboronic acid hydrochloride from p-bromo toluene has been developed via borylation, oxidation, nitration, esterification and hydrogenation.