Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-Disubstituted 1,3,4-Oxadiazole and 4,5-Disubstituted 1,2,4-Triazole-3-Thiol

Abstract

Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-… 28 anhydride. Oxazolinone (3,4) were treated with hydrazine hydrate to give acid hydrazides (5,6). Acid hydrazides were converted to substituted thiosemi-carbazides (7,8) by their reaction with phenyl isothiocyanate. Substituted thiosemicarbazides (7,8) were treated with sodium hydroxide and concentrated sulphuric acid give substituted 1,2,4-triazoles (9,10), 1,3,4-thiadiazoles (11,12) respectively while treatment of (7) with mercuric oxide gave 1,3,4-oxadiazoles (13). Treatment of triazoles (9,10) with 4-hydroxybenzaldehyde gave substituted triazoles (14,15). 1-Substituted thiosemicarbazide (16) was obtained from acid hydrazide (5), cyclized with sodium hydroxide to 5-Substituted-1,2,4-triazole-3-thiol (17). The structures of the synthesized compounds were confirmed by physical and spectral means.

Synthesis of Some New Substituted 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives

“…3421 (N-H), 1620 (C=O, 1743 (C=O), 1095 (C=S), the observation bands were found to be similar to the published in one similar compounds [21]. where as compound (8) the absorption bands for (N-H)3467, (C=O)1641, 1603 (C= N), 1462 (C=C aromatic), the observation bands were found to be similar to the published in one similar compounds [29]. compound (7) treatment.…”