Synthesis of (2-butyl-4-Substitutedthiamidothiocarbamido- 1- {[2-(1h-tetrazol 5-yl) biphenyl- 4-yl] methyl}-1h- imidazol-5-yl) Methanol

Abstract

Heteroacyclic and Heterocyclic containing drugs showed remarkable and noticeable drug absorption, transmission and drug effects; hence they created their own identity and importance in pharmaceutical, medicinal, agricultural and drug sciences. Thioamido, pyridino, thiobiureto and alkylamino heterocyclic compounds showed various significances and applications in industrial, pharmaceutical, medicinal and drug chemistry. Considering all these facts into consideration it was thought interesting to synthesize( 2-butyl-4-substitutedthiamidothiocarbamido-1-{[2-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl}-1H-imidazol-5-yl) methanol(5) by interacting (2-butyl-4-thiocarbamido-1-{[2-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl}-1H-imidazol-5-yl) methanol(3) with various isothiocynates(4) in ethanol-acetone medium. The( 2-butyl-4-thiocarbamido-1-{[2-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl}-1H-imidazol-5-yl) methanol(3) was synthesized by interacting( 2-butyl-4 chloro-1-{[2-(1H-tetrazol-5yl) biphenyl 4yl ] methyl}-1H -imidazol-5-yl) methanol (1) with thiourea (2) in isopropanol medium. The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characterization, elemental analysis, and through spectral data.